Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | TLR9 | Q9NR96 | 4/20 | 0.46 |
| ▸ | TLR7 | Q9NYK1 | 2/20 | 0.46 |
| ▸ | CNR1 | P21554 | 1/20 | 0.46 |
| ▸ | CNR2 | P34972 | 1/20 | 0.46 |
| ▸ | NPC1 | O15118 | 2/20 | 0.43 |
| ▸ | RAB9A | P51151 | 2/20 | 0.43 |
| ▸ | MEN1 | O00255 | 1/20 | 0.43 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.43 |
| ▸ | PKM | P14618 | 1/20 | 0.43 |
| ▸ | SRD5A1 | P18405 | 1/20 | 0.43 |
| ▸ | SRD5A2 | P31213 | 1/20 | 0.43 |
| ▸ | TRPC6 | Q9Y210 | 1/20 | 0.41 |
| ▸ | APP | P05067 | 2/20 | 0.40 |
| ▸ | PIM1 | P11309 | 1/20 | 0.39 |
| ▸ | MARK3 | P27448 | 1/20 | 0.39 |
| ▸ | MAP4K2 | Q12851 | 1/20 | 0.39 |
| ▸ | CAMK2B | Q13554 | 1/20 | 0.39 |
| ▸ | PIM3 | Q86V86 | 1/20 | 0.39 |
| ▸ | PIM2 | Q9P1W9 | 1/20 | 0.39 |
| ▸ | AGTR2 | P50052 | 1/20 | 0.39 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL1777494 | 0.82 | TLR9 (0.49) | TLR9TLR7CNR1CNR2NPC1 | |
| SCHEMBL3101171 | 0.82 | TLR9 (0.49) | TLR9TLR7CNR1CNR2NPC1 | |
| SCHEMBL17417658 | 0.82 | SRD5A1 (0.50) | TLR9TLR7CNR1CNR2NPC1 | |
| SCHEMBL1748816 | 0.81 | TLR9 (0.50) | TLR9TLR7CNR1CNR2NPC1 | |
| SCHEMBL18474480 | 0.81 | PDE4B (0.39) | TLR9CNR1CNR2PIM1MARK3 | |
| SCHEMBL17423709 | 0.81 | TLR9 (0.47) | TLR9TLR7CNR1CNR2NPC1 | |
| SCHEMBL18474404 | 0.79 | HTR2A (0.38) | MEN1KMT2APIM1MARK3MAP4K2 | |
| SCHEMBL18474477 | 0.78 | PDE4B (0.39) | PIM1MARK3MAP4K2CAMK2BPIM3 | |
| SCHEMBL20580937 | 0.75 | TLR9 (0.45) | TLR9TLR7CNR1CNR2NPC1 | |
| SCHEMBL18474166 | 0.75 | SRD5A1 (0.55) | TLR9TLR7NPC1RAB9AMEN1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| WO-2017023894-A1 | MTHFD2 INHIBITORS AND USES THEREOF | RAZE THERAPEUTICS, INC. (US) | 2017-02-09 | — | — | WO | disclosed |