SCHEMBL17423709

SCHEMBL17423709

COc1cc2c([C]=O)cn(C(=O)OC(C)(C)C)c2cc1OCc1ccccc1

nearest known ligand 0.47

Predicted protein targets (top 20)

geneUniProtsupporting neighboursconfidence
TLR9 Q9NR96 4/20 0.47
TLR7 Q9NYK1 2/20 0.47
SRD5A1 P18405 2/20 0.46
SRD5A2 P31213 2/20 0.46
CNR1 P21554 1/20 0.41
CNR2 P34972 1/20 0.41
HPGD P15428 2/20 0.40
NPC1 O15118 1/20 0.40
RAB9A P51151 1/20 0.40
SMN1; SMN2 Q16637 1/20 0.40
CTSV O60911 2/20 0.40
CTSL P07711 2/20 0.40
SMPD1 P17405 1/20 0.40
HDAC1 Q13547 1/20 0.40
HDAC8 Q9BY41 1/20 0.40
HDAC6 Q9UBN7 1/20 0.40
CHRNA7 P36544 2/20 0.39
KDM4E B2RXH2 1/20 0.39
ALDH1A1 P00352 1/20 0.39
PLK1 P53350 1/20 0.39

Click a target to see other patent compounds predicted against it — the reverse direction, in place.

Similar compounds — the chemically nearest patent molecules

Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.

Compoundsimilaritytop predictedshared targets
SCHEMBL17417658 0.86 SRD5A1 (0.50) TLR9TLR7SRD5A1SRD5A2CNR1
SCHEMBL3101171 0.86 TLR9 (0.49) TLR9TLR7SRD5A1SRD5A2CNR1
SCHEMBL1777494 0.86 TLR9 (0.49) TLR9TLR7SRD5A1SRD5A2CNR1
SCHEMBL1748816 0.85 TLR9 (0.50) TLR9TLR7SRD5A1SRD5A2CNR1
SCHEMBL18474167 0.81 TLR9 (0.46) TLR9TLR7SRD5A1SRD5A2CNR1
SCHEMBL18474166 0.79 SRD5A1 (0.55) TLR9TLR7SRD5A1SRD5A2HPGD
SCHEMBL20581146 0.74 TLR9 (0.47) TLR9TLR7SRD5A1SRD5A2CNR1
SCHEMBL20580872 0.74 TLR9 (0.49) TLR9TLR7SRD5A1SRD5A2CNR1
SCHEMBL29122828 0.73 L3MBTL1 (0.41) TLR9CTSLKDM4EMTNR1AMTNR1B
SCHEMBL20580546 0.73 TLR9 (0.48) TLR9TLR7SRD5A1SRD5A2CNR1

Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.

Patent provenance — the patents this molecule appears in, and who filed them

Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.

PatentTitleAssigneePublishedPriorityFilingCountryStatus
EP-3166940-A1 QUINUCLIDINE COMPOUNDS FOR MODULATING ALPHA7 -NICOTINIC ACETYLCHOLINE RECEPTOR ACTIVITY Alpharmagen, LLC (US) 2017-05-17 EP disclosed
WO-2016007630-A1 QUINUCLIDINE COMPOUNDS FOR MODULATING ALPHA7 -NICOTINIC ACETYLCHOLINE RECEPTOR ACTIVITY ALPHARMAGEN, LLC (US) 2016-01-14 WO disclosed