Predicted protein targets (top 13)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | HSD17B10 | Q99714 | 1/20 | 0.47 |
| ▸ | GAA | P10253 | 1/20 | 0.47 |
| ▸ | HCAR1 | Q9BXC0 | 5/20 | 0.47 |
| ▸ | IDO1 | P14902 | 7/20 | 0.46 |
| ▸ | KCNH2 | Q12809 | 5/20 | 0.46 |
| ▸ | ALDH1A1 | P00352 | 2/20 | 0.43 |
| ▸ | NPC1 | O15118 | 1/20 | 0.43 |
| ▸ | HPGD | P15428 | 1/20 | 0.43 |
| ▸ | ATM | Q13315 | 1/20 | 0.42 |
| ▸ | PRPS1 | P60891 | 1/20 | 0.42 |
| ▸ | TP53 | P04637 | 1/20 | 0.41 |
| ▸ | MAP3K14 | Q99558 | 1/20 | 0.40 |
| ▸ | CYP2C9 | P11712 | 1/20 | 0.40 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL4677284 | 0.88 | IDO1 (0.45) | HSD17B10GAAIDO1KCNH2PRPS1 | |
| SCHEMBL4677288 | 0.86 | PRKCI (0.53) | IDO1KCNH2PRPS1CYP2C9 | |
| SCHEMBL30914210 | 0.81 | GAA (0.50) | HSD17B10GAAALDH1A1NPC1HPGD | |
| SCHEMBL17678351 | 0.81 | GAA (0.47) | HSD17B10GAAHCAR1ALDH1A1NPC1 | |
| SCHEMBL17678098 | 0.81 | GAA (0.47) | HSD17B10GAAHCAR1ALDH1A1NPC1 | |
| SCHEMBL24463552 | 0.79 | GAA (0.43) | HSD17B10GAAHCAR1ALDH1A1NPC1 | |
| SCHEMBL31228863 | 0.77 | GAA (0.50) | HSD17B10GAAHCAR1ALDH1A1NPC1 | |
| SCHEMBL7025961 | 0.77 | DDB1 (0.56) | HSD17B10GAAHCAR1ALDH1A1NPC1 | |
| SCHEMBL15741977 | 0.77 | GAA (0.43) | HSD17B10GAAHCAR1KCNH2ALDH1A1 | |
| SCHEMBL18136684 | 0.77 | GAA (0.50) | HSD17B10GAAHCAR1ALDH1A1NPC1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| WO-2017023894-A1 | MTHFD2 INHIBITORS AND USES THEREOF | RAZE THERAPEUTICS, INC. (US) | 2017-02-09 | — | — | WO | disclosed |