Predicted protein targets (top 12)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | PRKCI | P41743 | 3/20 | 0.53 |
| ▸ | IRAK4 | Q9NWZ3 | 2/20 | 0.50 |
| ▸ | IDO1 | P14902 | 7/20 | 0.44 |
| ▸ | KCNH2 | Q12809 | 5/20 | 0.44 |
| ▸ | JAK2 | O60674 | 1/20 | 0.44 |
| ▸ | JAK1 | P23458 | 1/20 | 0.44 |
| ▸ | PRPS1 | P60891 | 1/20 | 0.42 |
| ▸ | PRMT5 | O14744 | 2/20 | 0.40 |
| ▸ | HTR2C | P28335 | 1/20 | 0.39 |
| ▸ | HTR2B | P41595 | 1/20 | 0.39 |
| ▸ | KDM5B | Q9UGL1 | 1/20 | 0.39 |
| ▸ | CYP2C9 | P11712 | 1/20 | 0.39 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL4671267 | 0.90 | IRAK4 (0.51) | PRKCIIRAK4JAK2JAK1PRPS1 | |
| SCHEMBL30610095 | 0.90 | IRAK4 (0.51) | PRKCIIRAK4JAK2JAK1PRPS1 | |
| Piperazine SCHEMBL28324587 | 0.88 | IRAK4 (0.50) | PRKCIIRAK4IDO1JAK2JAK1 | |
| SCHEMBL18474192 | 0.86 | HSD17B10 (0.47) | IDO1KCNH2PRPS1CYP2C9 | |
| SCHEMBL4677284 | 0.84 | IDO1 (0.45) | PRKCIIRAK4IDO1KCNH2PRPS1 | |
| SCHEMBL15833600 | 0.82 | PRKCI (0.53) | PRKCIIRAK4JAK2JAK1PRMT5 | |
| SCHEMBL15825750 | 0.82 | PRKCI (0.53) | PRKCIJAK2JAK1PRMT5 | |
| SCHEMBL4753958 | 0.82 | PRKCI (0.53) | PRKCIIDO1KCNH2JAK2JAK1 | |
| SCHEMBL1868695 | 0.82 | DDB1 (0.55) | PRKCIJAK2JAK1PRMT5KDM5B | |
| SCHEMBL18787932 | 0.79 | PRKCI (0.50) | PRKCIIRAK4IDO1JAK2JAK1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 4 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| WO-2008146064-A1 | NEW BENZOFURAN DERIVATIVES AS SELECTIVE 5HT7 RECEPTOR INHIBITORS AND PROCESS FOR THEIR PREPARATION | EGIS GYÓGYSZERGYÁR (HU) | 2008-12-04 | — | — | WO | disclosed |
| EP-0958287-B2 | SULFAMIDE-METALLOPROTEASE INHIBITORS | HOFFMANN LA ROCHE (CH) | 2008-04-09 | — | — | EP | disclosed |
| EP-0958287-B1 | SULFAMIDE-METALLOPROTEASE INHIBITORS | HOFFMANN LA ROCHE (CH) | 2002-09-11 | — | — | EP | disclosed |
| US-6376506-B1 | REACTING SULFAMOYL OXAZOLIDONE WITH (1,2,3,4)-TETRAHYDRO-BETA-CARBOLINE TO FORM INHIBITOR; USED TO TREAT ARTHRITIS, OSTEOPOROSIS, PERIODONTAL DISEASE, CARDIOVASCULAR DISEASES, MULTIPLE SCLEROSIS, AND TUMORS | SYNTEX (U.S.A.) LLC | 2002-04-23 | — | — | US | disclosed |