Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | PIK3C3 | Q8NEB9 | 1/20 | 0.50 |
| ▸ | CDK4 | P11802 | 12/20 | 0.49 |
| ▸ | GSK3B | P49841 | 8/20 | 0.49 |
| ▸ | CDK2 | P24941 | 4/20 | 0.49 |
| ▸ | CDK1 | P06493 | 5/20 | 0.48 |
| ▸ | CCNB1 | P14635 | 5/20 | 0.48 |
| ▸ | CSNK1A1 | P48729 | 3/20 | 0.48 |
| ▸ | CDK7 | P50613 | 3/20 | 0.48 |
| ▸ | MAPK8 | P45983 | 3/20 | 0.48 |
| ▸ | MAPK9 | P45984 | 3/20 | 0.48 |
| ▸ | CSNK1D | P48730 | 2/20 | 0.48 |
| ▸ | CCNB2 | O95067 | 2/20 | 0.48 |
| ▸ | CCNB3 | Q8WWL7 | 2/20 | 0.48 |
| ▸ | CDC7 | O00311 | 1/20 | 0.48 |
| ▸ | CHEK1 | O14757 | 1/20 | 0.48 |
| ▸ | DCLK1 | O15075 | 1/20 | 0.48 |
| ▸ | MAPK13 | O15264 | 1/20 | 0.48 |
| ▸ | PDPK1 | O15530 | 1/20 | 0.48 |
| ▸ | DAPK3 | O43293 | 1/20 | 0.48 |
| ▸ | DYRK3 | O43781 | 1/20 | 0.48 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL20421778 | 1.00 | PIK3C3 (0.50) | PIK3C3CDK4GSK3BCDK2CDK1 | |
| SCHEMBL20445324 | 0.91 | CDK4 (0.53) | PIK3C3CDK4GSK3BCDK2CDK1 | |
| SCHEMBL8233031 | 0.84 | PIK3C3 (0.54) | PIK3C3CDK4GSK3BCDK2CDK1 | |
| SCHEMBL5311805 | 0.82 | PIK3C3 (0.58) | PIK3C3CDK4GSK3BCDK2CDK1 | |
| SCHEMBL5311802 | 0.82 | PIK3C3 (0.58) | PIK3C3CDK4GSK3BCDK2CDK1 | |
| SCHEMBL20445322 | 0.81 | CDK4 (0.46) | PIK3C3CDK4GSK3BCDK2CDK1 | |
| SCHEMBL19629622 | 0.79 | CSNK1A1 (0.67) | PIK3C3CDK4GSK3BCDK2CDK1 | |
| SCHEMBL20421794 | 0.79 | CSNK1A1 (0.67) | PIK3C3CDK4GSK3BCDK2CDK1 | |
| SCHEMBL19629620 | 0.79 | CSNK1A1 (0.67) | PIK3C3CDK4GSK3BCDK2CDK1 | |
| SCHEMBL20445312 | 0.78 | PIK3C3 (0.52) | PIK3C3CDK4GSK3BCDK2CDK1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 10 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-20240207268-A1 | PYRAZOLYLPYRIMIDINES FOR TREATING MALIGNANT SOLID TUMOR | YISSUM RESEARCH DEVELOPMENT COMPANY OF THE HEBREW UNIVERSITY OF JERUSALEM LTD. (IL) | 2024-06-27 | — | — | US | disclosed |
| US-20240207268-A1 | PYRAZOLYLPYRIMIDINES FOR TREATING MALIGNANT SOLID TUMOR | YISSUM RESEARCH DEVELOPMENT COMPANY OF THE HEBREW UNIVERSITY OF JERUSALEM LTD. (IL) | 2024-06-27 | — | — | US | disclosed |
| US-20230047732-A1 | PYRAZOLYLPYRIMIDINES AND USE THEREOF | YISSUM RESEARCH DEVELOPMENT COMPANY OF THE HEBREW UNIVERSITY OF JERUSALEM, LTD. (IL) | 2023-02-16 | — | — | US | disclosed |
| EP-3331877-B1 | PYRAZOLE PYRIMIDINE DERIVATIVE AND USES THEREOF | YISSUM RES DEV CO OF HEBREW UNIV JERUSALEM LTD (IL) | 2021-09-22 | — | — | EP | disclosed |
| US-20210251992-A1 | PYRAZOLE PYRIMIDINE DERIVATIVE AND USES THEREOF | YISSUM RESEARCH DEVELOPMENT COMPANY OF THE HEBREW UNIVERSITY OF JERUSALEM LTD. (IL) | 2021-08-19 | — | — | US | disclosed |
| WO-2021146220-A1 | PYRAZOLYLPYRIMIDINES AND USE THEREOF | BIOTHERYX, INC. (US) | 2021-07-22 | — | — | WO | disclosed |
| US-10960003-B2 | Pyrazole pyrimidine derivative and uses thereof | BIOTHERYX, INC. (US) | 2021-03-30 | — | — | US | disclosed |
| US-10376511-B2 | Pyrazole pyrimidine derivative and uses thereof | YISSUM RESEARCH DEVELOPMENT COMPANY OF THE HEBREW UNIVERSITY OF JERUSALEM LTD. (IL) | 2019-08-13 | — | — | US | disclosed |
| US-20180214447-A1 | PYRAZOLE PYRIMIDINE DERIVATIVE AND USES THEREOF | YISSUM RESEARCH DEVELOPMENT COMPANY OF THE HEBREW UNIVERSITY OF JERUSALEM LTD. ISRAELI COMPANY, OF (IL) | 2018-08-02 | — | — | US | disclosed |
| WO-2017021969-A1 | PYRAZOLE PYRIMIDINE DERIVATIVE AND USES THEREOF | YISSUM RESEARCH DEVELOPMENT COMPANY OF THE HEBREW UNIVERSITY OF JERUSALEM LTD (IL) | 2017-02-09 | — | — | WO | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (6 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-10960003-B2 | Pyrazole pyrimidine derivative and uses thereof | IRAK1, IRAK2, IRAK3 | PIK3C3 403/4885CDK4 85/4885GSK3B 459/4885 |
| US-20210251992-A1 | PYRAZOLE PYRIMIDINE DERIVATIVE AND USES THEREOF | IRAK1, IRAK2, IRAK3 | PIK3C3 403/4885CDK4 85/4885GSK3B 459/4885 |
| US-20240207268-A1 | PYRAZOLYLPYRIMIDINES FOR TREATING MALIGNANT SOLID TUMOR | VHL, TP53, TYMP | PIK3C3 2935/4885CDK4 48/4885GSK3B 1800/4885 |
| US-10376511-B2 | Pyrazole pyrimidine derivative and uses thereof | IRAK1, IRAK2, IRAK3 | PIK3C3 403/4885CDK4 85/4885GSK3B 459/4885 |
| US-20180214447-A1 | PYRAZOLE PYRIMIDINE DERIVATIVE AND USES THEREOF | IRAK1, IRAK2, IRAK3 | PIK3C3 403/4885CDK4 85/4885GSK3B 459/4885 |
| US-20230047732-A1 | PYRAZOLYLPYRIMIDINES AND USE THEREOF | MCL1, THPO, FLT3 | PIK3C3 1289/4885CDK4 507/4885GSK3B 4553/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.