Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | PIK3C3 | Q8NEB9 | 3/20 | 0.58 |
| ▸ | GSK3B | P49841 | 9/20 | 0.53 |
| ▸ | CDK1 | P06493 | 5/20 | 0.53 |
| ▸ | CCNB1 | P14635 | 5/20 | 0.53 |
| ▸ | CCNB2 | O95067 | 3/20 | 0.53 |
| ▸ | CCNB3 | Q8WWL7 | 3/20 | 0.53 |
| ▸ | CSNK1A1 | P48729 | 3/20 | 0.53 |
| ▸ | CDK7 | P50613 | 3/20 | 0.53 |
| ▸ | CSNK1D | P48730 | 2/20 | 0.53 |
| ▸ | RET | P07949 | 2/20 | 0.53 |
| ▸ | CDC7 | O00311 | 1/20 | 0.53 |
| ▸ | CHEK1 | O14757 | 1/20 | 0.53 |
| ▸ | DCLK1 | O15075 | 1/20 | 0.53 |
| ▸ | MAPK13 | O15264 | 1/20 | 0.53 |
| ▸ | PDPK1 | O15530 | 1/20 | 0.53 |
| ▸ | DAPK3 | O43293 | 1/20 | 0.53 |
| ▸ | DYRK3 | O43781 | 1/20 | 0.53 |
| ▸ | JAK2 | O60674 | 1/20 | 0.53 |
| ▸ | PRKD3 | O94806 | 1/20 | 0.53 |
| ▸ | MAP4K4 | O95819 | 1/20 | 0.53 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL5311805 | 1.00 | PIK3C3 (0.58) | PIK3C3GSK3BCDK1CCNB1CCNB2 | |
| SCHEMBL8233031 | 0.86 | PIK3C3 (0.54) | PIK3C3GSK3BCDK1CCNB1CCNB2 | |
| SCHEMBL5315804 | 0.83 | CDK4 (0.47) | PIK3C3GSK3BCDK1CCNB1CCNB2 | |
| SCHEMBL5315799 | 0.83 | CDK4 (0.47) | PIK3C3GSK3BCDK1CCNB1CCNB2 | |
| SCHEMBL5314460 | 0.82 | CDK4 (0.47) | PIK3C3GSK3BCDK1CCNB1CCNB2 | |
| SCHEMBL5314457 | 0.82 | CDK4 (0.47) | PIK3C3GSK3BCDK1CCNB1CCNB2 | |
| SCHEMBL19629622 | 0.82 | CSNK1A1 (0.67) | PIK3C3GSK3BCDK1CCNB1CCNB2 | |
| SCHEMBL18480508 | 0.82 | PIK3C3 (0.50) | PIK3C3GSK3BCDK1CCNB1CCNB2 | |
| SCHEMBL20421794 | 0.82 | CSNK1A1 (0.67) | PIK3C3GSK3BCDK1CCNB1CCNB2 | |
| SCHEMBL20421778 | 0.82 | PIK3C3 (0.50) | PIK3C3GSK3BCDK1CCNB1CCNB2 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| WO-2007129195-A2 | 4-PYRIMIDINE-5-AMINO-PYRAZOLE COMPOUNDS | PFIZER PRODUCTS INC. (US) | 2007-11-15 | — | — | WO | disclosed |