Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | CSNK1A1 | P48729 | 2/20 | 0.55 |
| ▸ | CDK7 | P50613 | 2/20 | 0.55 |
| ▸ | CDK9 | P50750 | 2/20 | 0.55 |
| ▸ | CCNK | O75909 | 1/20 | 0.55 |
| ▸ | CDK13 | Q14004 | 1/20 | 0.55 |
| ▸ | CDK12 | Q9NYV4 | 1/20 | 0.55 |
| ▸ | CCNT1 | O60563 | 1/20 | 0.55 |
| ▸ | CSNK1D | P48730 | 1/20 | 0.55 |
| ▸ | CSNK1E | P49674 | 1/20 | 0.55 |
| ▸ | CCNH | P51946 | 1/20 | 0.55 |
| ▸ | PIK3C3 | Q8NEB9 | 5/20 | 0.53 |
| ▸ | PIK3CD | O00329 | 2/20 | 0.53 |
| ▸ | PIK3CA | P42336 | 1/20 | 0.53 |
| ▸ | PIK3CG | P48736 | 1/20 | 0.53 |
| ▸ | PI4KB | Q9UBF8 | 1/20 | 0.53 |
| ▸ | CDK4 | P11802 | 12/20 | 0.50 |
| ▸ | GSK3B | P49841 | 7/20 | 0.50 |
| ▸ | CDK2 | P24941 | 4/20 | 0.50 |
| ▸ | CDK1 | P06493 | 3/20 | 0.46 |
| ▸ | CCNA2 | P20248 | 3/20 | 0.46 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL20421895 | 1.00 | CSNK1A1 (0.55) | CSNK1A1CDK7CDK9CCNKCDK13 | |
| SCHEMBL19629618 | 1.00 | CSNK1A1 (0.55) | CSNK1A1CDK7CDK9CCNKCDK13 | |
| SCHEMBL19629619 | 0.92 | CSNK1A1 (0.55) | CSNK1A1CDK7CDK9CCNKCDK13 | |
| SCHEMBL19630864 | 0.92 | CSNK1A1 (0.55) | CSNK1A1CDK7CDK9CCNKCDK13 | |
| SCHEMBL20421794 | 0.91 | CSNK1A1 (0.67) | CSNK1A1CDK7CDK9CCNKCDK13 | |
| SCHEMBL19629622 | 0.91 | CSNK1A1 (0.67) | CSNK1A1CDK7CDK9CCNKCDK13 | |
| SCHEMBL19629620 | 0.91 | CSNK1A1 (0.67) | CSNK1A1CDK7CDK9CCNKCDK13 | |
| SCHEMBL18480113 | 0.90 | PIK3C3 (0.61) | CSNK1A1CDK7CDK9CCNKCDK13 | |
| SCHEMBL25025606 | 0.89 | PIK3C3 (0.55) | CSNK1A1CDK7CDK9CCNKCDK13 | |
| SCHEMBL20421786 | 0.89 | CSNK1A1 (0.52) | CSNK1A1CDK7CDK9CCNKCDK13 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 10 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-20240207268-A1 | PYRAZOLYLPYRIMIDINES FOR TREATING MALIGNANT SOLID TUMOR | YISSUM RESEARCH DEVELOPMENT COMPANY OF THE HEBREW UNIVERSITY OF JERUSALEM LTD. (IL) | 2024-06-27 | — | — | US | disclosed |
| US-20230047732-A1 | PYRAZOLYLPYRIMIDINES AND USE THEREOF | YISSUM RESEARCH DEVELOPMENT COMPANY OF THE HEBREW UNIVERSITY OF JERUSALEM, LTD. (IL) | 2023-02-16 | — | — | US | disclosed |
| EP-3331877-B1 | PYRAZOLE PYRIMIDINE DERIVATIVE AND USES THEREOF | YISSUM RES DEV CO OF HEBREW UNIV JERUSALEM LTD (IL) | 2021-09-22 | — | — | EP | disclosed |
| US-20210251992-A1 | PYRAZOLE PYRIMIDINE DERIVATIVE AND USES THEREOF | YISSUM RESEARCH DEVELOPMENT COMPANY OF THE HEBREW UNIVERSITY OF JERUSALEM LTD. (IL) | 2021-08-19 | — | — | US | disclosed |
| WO-2021146220-A1 | PYRAZOLYLPYRIMIDINES AND USE THEREOF | BIOTHERYX, INC. (US) | 2021-07-22 | — | — | WO | disclosed |
| US-10960003-B2 | Pyrazole pyrimidine derivative and uses thereof | BIOTHERYX, INC. (US) | 2021-03-30 | — | — | US | disclosed |
| WO-2019173224-A1 | DEUTERATED COMPOUNDS AND CHIMERAS AND USES THEREOF | BIOTHERYX, INC. (US) | 2019-09-12 | — | — | WO | disclosed |
| US-10376511-B2 | Pyrazole pyrimidine derivative and uses thereof | YISSUM RESEARCH DEVELOPMENT COMPANY OF THE HEBREW UNIVERSITY OF JERUSALEM LTD. (IL) | 2019-08-13 | — | — | US | disclosed |
| US-20180214447-A1 | PYRAZOLE PYRIMIDINE DERIVATIVE AND USES THEREOF | YISSUM RESEARCH DEVELOPMENT COMPANY OF THE HEBREW UNIVERSITY OF JERUSALEM LTD. ISRAELI COMPANY, OF (IL) | 2018-08-02 | — | — | US | disclosed |
| WO-2017021969-A1 | PYRAZOLE PYRIMIDINE DERIVATIVE AND USES THEREOF | YISSUM RESEARCH DEVELOPMENT COMPANY OF THE HEBREW UNIVERSITY OF JERUSALEM LTD (IL) | 2017-02-09 | — | — | WO | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (6 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-10960003-B2 | Pyrazole pyrimidine derivative and uses thereof | IRAK1, IRAK2, IRAK3 | CSNK1A1 5/4885CDK7 238/4885CDK9 137/4885 |
| US-20210251992-A1 | PYRAZOLE PYRIMIDINE DERIVATIVE AND USES THEREOF | IRAK1, IRAK2, IRAK3 | CSNK1A1 5/4885CDK7 238/4885CDK9 137/4885 |
| US-20240207268-A1 | PYRAZOLYLPYRIMIDINES FOR TREATING MALIGNANT SOLID TUMOR | VHL, TP53, TYMP | CSNK1A1 1246/4885CDK7 451/4885CDK9 472/4885 |
| US-10376511-B2 | Pyrazole pyrimidine derivative and uses thereof | IRAK1, IRAK2, IRAK3 | CSNK1A1 5/4885CDK7 238/4885CDK9 137/4885 |
| US-20180214447-A1 | PYRAZOLE PYRIMIDINE DERIVATIVE AND USES THEREOF | IRAK1, IRAK2, IRAK3 | CSNK1A1 5/4885CDK7 238/4885CDK9 137/4885 |
| US-20230047732-A1 | PYRAZOLYLPYRIMIDINES AND USE THEREOF | MCL1, THPO, FLT3 | CSNK1A1 4254/4885CDK7 427/4885CDK9 487/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.