Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | MAPT | P10636 | 1/20 | 0.38 |
| ▸ | TDP1 | Q9NUW8 | 1/20 | 0.38 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.37 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.37 |
| ▸ | HPGD | P15428 | 1/20 | 0.37 |
| ▸ | CYP19A1 | P11511 | 1/20 | 0.37 |
| ▸ | NQO2 | P16083 | 1/20 | 0.37 |
| ▸ | CA2 | P00918 | 2/20 | 0.37 |
| ▸ | SMN1; SMN2 | Q16637 | 2/20 | 0.36 |
| ▸ | NPC1 | O15118 | 1/20 | 0.36 |
| ▸ | RAB9A | P51151 | 1/20 | 0.36 |
| ▸ | L3MBTL1 | Q9Y468 | 1/20 | 0.36 |
| ▸ | CA12 | O43570 | 1/20 | 0.36 |
| ▸ | CA1 | P00915 | 1/20 | 0.36 |
| ▸ | CA4 | P22748 | 1/20 | 0.36 |
| ▸ | CA7 | P43166 | 1/20 | 0.36 |
| ▸ | CA9 | Q16790 | 1/20 | 0.36 |
| ▸ | CA14 | Q9ULX7 | 1/20 | 0.36 |
| ▸ | ACHE | P22303 | 1/20 | 0.36 |
| ▸ | APP | P05067 | 1/20 | 0.35 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL27692334 | 0.85 | ALDH1A1 (0.41) | MAPTTDP1KDM4EALDH1A1CYP19A1 | |
| SCHEMBL9826944 | 0.83 | IDO1 (0.42) | MAPTTDP1ALDH1A1SMN1; SMN2RAB9A | |
| Hydrochloric Acid SCHEMBL9793088 | 0.81 | EP300 (0.44) | MAPTTDP1ALDH1A1SMN1; SMN2RAB9A | |
| SCHEMBL10956458 | 0.77 | MAPT (0.62) | MAPTTDP1KDM4EALDH1A1HPGD | |
| SCHEMBL18535891 | 0.76 | MAPT (0.33) | MAPTTDP1KDM4E | |
| SCHEMBL3674074 | 0.76 | CA9 (0.50) | MAPTTDP1KDM4EALDH1A1HPGD | |
| SCHEMBL30701949 | 0.76 | CA9 (0.50) | MAPTTDP1KDM4EALDH1A1HPGD | |
| SCHEMBL14655577 | 0.76 | PGK1 (0.40) | MAPTKDM4EALDH1A1HPGDSMN1; SMN2 | |
| SCHEMBL5299244 | 0.76 | SMN1; SMN2 (0.40) | MAPTTDP1KDM4EALDH1A1HPGD | |
| SCHEMBL27777558 | 0.76 | MAPT (0.47) | MAPTTDP1KDM4EALDH1A1SMN1; SMN2 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| WO-2017024319-A1 | TUNABLE ENDOGENOUS PROTEIN DEGRADATION | DANA-FARBER CANCER INSTITUTE, INC. (US) | 2017-02-09 | — | — | WO | disclosed |