Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | MAPT | P10636 | 3/20 | 0.40 |
| ▸ | MAPK1 | P28482 | 1/20 | 0.40 |
| ▸ | KMT2A | Q03164 | 2/20 | 0.36 |
| ▸ | NPSR1 | Q6W5P4 | 2/20 | 0.36 |
| ▸ | POLB | P06746 | 3/20 | 0.36 |
| ▸ | SLC2A1 | P11166 | 1/20 | 0.34 |
| ▸ | CYP1A2 | P05177 | 2/20 | 0.33 |
| ▸ | CYP3A4 | P08684 | 2/20 | 0.33 |
| ▸ | ALDH1A1 | P00352 | 2/20 | 0.33 |
| ▸ | MEN1 | O00255 | 1/20 | 0.33 |
| ▸ | LMNA | P02545 | 1/20 | 0.33 |
| ▸ | ALPG | P10696 | 1/20 | 0.33 |
| ▸ | ATM | Q13315 | 1/20 | 0.33 |
| ▸ | TLR9 | Q9NR96 | 1/20 | 0.33 |
| ▸ | TDP1 | Q9NUW8 | 1/20 | 0.33 |
| ▸ | L3MBTL1 | Q9Y468 | 1/20 | 0.33 |
| ▸ | CYP2C9 | P11712 | 1/20 | 0.33 |
| ▸ | CYP2C19 | P33261 | 1/20 | 0.33 |
| ▸ | HPGD | P15428 | 1/20 | 0.33 |
| ▸ | CYP1A1 | P04798 | 1/20 | 0.33 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL1850663 | 0.88 | MAPT (0.46) | MAPTMAPK1KMT2ANPSR1POLB | |
| SCHEMBL1850661 | 0.88 | MAPT (0.46) | MAPTMAPK1KMT2ANPSR1POLB | |
| SCHEMBL1848488 | 0.87 | MAPT (0.41) | MAPTMAPK1KMT2ANPSR1POLB | |
| SCHEMBL5353608 | 0.74 | CES2 (0.50) | KMT2ACYP1A2CYP3A4ALDH1A1MEN1 | |
| SCHEMBL5353609 | 0.74 | CES2 (0.50) | KMT2ACYP1A2CYP3A4ALDH1A1MEN1 | |
| SCHEMBL15733269 | 0.73 | LMNA (0.53) | MAPTKMT2ANPSR1POLBALDH1A1 | |
| SCHEMBL15733270 | 0.73 | LMNA (0.53) | MAPTKMT2ANPSR1POLBALDH1A1 | |
| SCHEMBL9961399 | 0.73 | KMT2A (0.50) | MAPTKMT2ANPSR1CYP1A2CYP3A4 | |
| SCHEMBL14519363 | 0.73 | KMT2A (0.50) | MAPTKMT2ANPSR1CYP1A2CYP3A4 | |
| SCHEMBL1852265 | 0.71 | HSD17B10 (0.51) | NPSR1HPGDGRM5 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-2324008-A1 | 3,4-DIARYLPYRAZOLES AS PROTEIN KINASE INHIBITORS | NERVIANO MEDICAL SCIENCES S.R.L. (IT) | 2011-05-25 | — | — | EP | disclosed |
| WO-2010010154-A1 | 3,4-DIARYLPYRAZOLES AS PROTEIN KINASE INHIBITORS | NERVIANO MEDICAL SCIENCES S.R.L. (IT) | 2010-01-28 | — | — | WO | disclosed |