Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | GRIA1 | P42261 | 1/20 | 0.39 |
| ▸ | GABRG2 | P18507 | 3/20 | 0.36 |
| ▸ | GABRB3 | P28472 | 3/20 | 0.36 |
| ▸ | GABRA5 | P31644 | 3/20 | 0.36 |
| ▸ | GABRA1 | P14867 | 2/20 | 0.35 |
| ▸ | GABRA2 | P47869 | 2/20 | 0.35 |
| ▸ | GABRA6 | Q16445 | 2/20 | 0.35 |
| ▸ | NR1H2 | P55055 | 6/20 | 0.34 |
| ▸ | NR1H3 | Q13133 | 1/20 | 0.34 |
| ▸ | SQOR | Q9Y6N5 | 1/20 | 0.34 |
| ▸ | PDE3B | Q13370 | 1/20 | 0.34 |
| ▸ | PDE3A | Q14432 | 1/20 | 0.34 |
| ▸ | HDAC1 | Q13547 | 1/20 | 0.33 |
| ▸ | HDAC2 | Q92769 | 1/20 | 0.33 |
| ▸ | BTK | Q06187 | 1/20 | 0.33 |
| ▸ | TGFBR1 | P36897 | 1/20 | 0.33 |
| ▸ | MAP2K4 | P45985 | 1/20 | 0.32 |
| ▸ | NR3C2 | P08235 | 1/20 | 0.32 |
| ▸ | GABRA3 | P34903 | 1/20 | 0.32 |
| ▸ | GABRA4 | P48169 | 1/20 | 0.32 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL18486978 | 0.84 | GPR119 (0.37) | GABRG2GABRB3GABRA5GABRA1GABRA2 | |
| SCHEMBL18478247 | 0.83 | KIT (0.41) | GABRG2GABRB3GABRA5GABRA1GABRA2 | |
| SCHEMBL18480324 | 0.83 | MAPK13 (0.38) | GABRG2GABRB3GABRA5GABRA1GABRA2 | |
| SCHEMBL18437192 | 0.83 | GRIA1 (0.39) | GRIA1GABRG2GABRB3GABRA5GABRA1 | |
| SCHEMBL18475363 | 0.81 | GRIA1 (0.37) | GRIA1NR1H2NR1H3SQORHDAC1 | |
| SCHEMBL18485182 | 0.81 | NR1H2 (0.41) | NR1H2NR1H3 | |
| SCHEMBL18478250 | 0.79 | GBA1 (0.38) | GABRG2GABRB3GABRA5GABRA1GABRA2 | |
| SCHEMBL18476349 | 0.79 | CSNK1D (0.40) | GABRG2GABRB3GABRA5GABRA1GABRA2 | |
| SCHEMBL20435585 | 0.75 | MAP2K4 (0.37) | GABRG2GABRB3GABRA5GABRA1GABRA2 | |
| SCHEMBL18485086 | 0.74 | KDM4E (0.39) | GRIA1GABRG2GABRB3GABRA5GABRA1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| WO-2017024010-A1 | 3-(1H-PYRROLO[3,2-C]PYRIDIN-2-YL)-1H-INDAZOLES AND THERAPEUTIC USES THEREOF | SAMUMED, LLC. (US) | 2017-02-09 | — | — | WO | disclosed |