Predicted protein targets (top 17)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | GPR119 | Q8TDV5 | 3/20 | 0.37 |
| ▸ | GABRG2 | P18507 | 2/20 | 0.36 |
| ▸ | GABRB3 | P28472 | 2/20 | 0.36 |
| ▸ | GABRA5 | P31644 | 2/20 | 0.36 |
| ▸ | GABRA1 | P14867 | 1/20 | 0.34 |
| ▸ | GABRA2 | P47869 | 1/20 | 0.34 |
| ▸ | GABRA6 | Q16445 | 1/20 | 0.34 |
| ▸ | LRRK2 | Q5S007 | 3/20 | 0.32 |
| ▸ | NR1H2 | P55055 | 4/20 | 0.31 |
| ▸ | NR4A2 | P43354 | 1/20 | 0.31 |
| ▸ | ATR | Q13535 | 2/20 | 0.31 |
| ▸ | ATRIP | Q8WXE1 | 2/20 | 0.31 |
| ▸ | MAP2K4 | P45985 | 1/20 | 0.30 |
| ▸ | TDO2 | P48775 | 1/20 | 0.30 |
| ▸ | ELANE | P08246 | 1/20 | 0.30 |
| ▸ | AURKA | O14965 | 1/20 | 0.30 |
| ▸ | CDK2 | P24941 | 1/20 | 0.30 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL18485085 | 0.84 | GRIA1 (0.39) | GABRG2GABRB3GABRA5GABRA1GABRA2 | |
| SCHEMBL18437158 | 0.83 | GABRG2 (0.36) | GPR119GABRG2GABRB3GABRA5GABRA1 | |
| SCHEMBL18478247 | 0.82 | KIT (0.41) | GPR119GABRG2GABRB3GABRA5GABRA1 | |
| SCHEMBL18480324 | 0.78 | MAPK13 (0.38) | GABRG2GABRB3GABRA5GABRA1GABRA2 | |
| SCHEMBL18478250 | 0.78 | GBA1 (0.38) | GPR119GABRG2GABRB3GABRA5GABRA1 | |
| SCHEMBL18485086 | 0.74 | KDM4E (0.39) | GPR119GABRG2GABRB3GABRA5GABRA1 | |
| SCHEMBL20435587 | 0.72 | GABRG2 (0.36) | GPR119GABRG2GABRB3GABRA5GABRA1 | |
| SCHEMBL18478920 | 0.71 | GABRG2 (0.39) | GPR119GABRG2GABRB3GABRA5GABRA1 | |
| SCHEMBL18487992 | 0.71 | NR1H2 (0.38) | GPR119GABRG2GABRB3GABRA5GABRA1 | |
| SCHEMBL18483167 | 0.69 | MAPK14 (0.45) | GPR119GABRG2GABRB3GABRA5GABRA1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| WO-2017024010-A1 | 3-(1H-PYRROLO[3,2-C]PYRIDIN-2-YL)-1H-INDAZOLES AND THERAPEUTIC USES THEREOF | SAMUMED, LLC. (US) | 2017-02-09 | — | — | WO | disclosed |