Sugi Predict

Sugi Predict / Compounds / Jnj-7777120

Jnj-7777120

Jnj-7777120

SCHEMBL18486196

CN1CCN(C(=O)c2cc3cc(Cl)ccc3[nH]2)CC1.CN1CCN(C(=O)c2nc3cc(Cl)ccc3[nH]2)CC1

nearest known ligand 0.80

Full drug profile on Sugi Atlas →

Predicted protein targets (top 5)

geneUniProtsupporting neighboursconfidence
▸ HRH4 Q9H3N8 18/20 0.80
▸ HRH3 Q9Y5N1 6/20 0.80
▸ HRH1 P35367 1/20 0.80
▸ ALOX15 P16050 1/20 0.62
▸ KMT2A Q03164 1/20 0.60

Click a target to see other patent compounds predicted against it — the reverse direction, in place.

Similar compounds — the chemically nearest patent molecules

Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.

Compoundsimilaritytop predictedshared targets
SCHEMBL602043 0.92 HRH4 (0.81) HRH4HRH3HRH1ALOX15
Jnj-7777120 SCHEMBL29381532 0.90 HRH4 (1.00) HRH4HRH3HRH1KMT2A
Jnj-7777120 SCHEMBL186434 0.90 HRH4 (1.00) HRH4HRH3HRH1KMT2A
Maleic Acid SCHEMBL20162482 0.86 ALOX15 (0.84) HRH4HRH3HRH1ALOX15
Maleic Acid SCHEMBL29404707 0.86 ALOX15 (0.84) HRH4HRH3HRH1ALOX15
Fumaric Acid SCHEMBL602943 0.86 ALOX15 (0.84) HRH4HRH3HRH1ALOX15
Maleic Acid SCHEMBL602941 0.86 ALOX15 (0.84) HRH4HRH3HRH1ALOX15
SCHEMBL17938630 0.83 HRH4 (0.86) HRH4HRH3HRH1KMT2A
Jnj-7777120 SCHEMBL603853 0.83 HRH4 (0.86) HRH4HRH3HRH1ALOX15KMT2A
Jnj-7777120 SCHEMBL603855 0.83 HRH4 (0.86) HRH4HRH3HRH1ALOX15KMT2A

Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.

Patent provenance — the patents this molecule appears in, and who filed them

Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.

PatentTitleAssigneePublishedPriorityFilingCountryStatus
EP-3130376-A1 SELECTIVE HISTAMINE H4 RECEPTOR ANTAGONISTS FOR THE TREATMENT OF VESTIBULAR DISORDERS INSERM (Institut National de la Santé et de la Recherche Médicale) (FR) 2017-02-15 — — EP claimed