Known targets — ChEMBL curated mechanism
ACEADRA1AADRA1BADRA1DADRA2AADRA2BADRA2CADRB1ADRB2BTKCACNA1CCACNA1DCACNA1FCACNA1SCCR5CPT1BCPT2DPP4DRD1DRD2EGFRERBB2ERBB4HRH1HRH3HTR1AHTR2AHTR2BHTR2CHTR4JAK1JAK2JAK3MPLMTORPPIK3CAPIK3CBPIK3CDPIK3CGPIK3R1PIK3R2PIK3R3PIK3R5PPARGSLC6A2SLC6A3SLC6A4SMOTYK2pol
The experimentally established mechanism targets of Maleic Acid. The predicted profile below is derived independently by chemical similarity — agreement is a validation signal, a miss is honest.
Predicted protein targets (top 4)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | HRH3 known ✓ | Q9Y5N1 | 2/20 | 0.71 |
| ▸ | HRH1 known ✓ | P35367 | 1/20 | 0.58 |
| ▸ | ALOX15 | P16050 | 1/20 | 0.84 |
| ▸ | HRH4 | Q9H3N8 | 19/20 | 0.71 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| Maleic Acid SCHEMBL602941 | 1.00 | ALOX15 (0.84) | ALOX15HRH4HRH3HRH1 | |
| Fumaric Acid SCHEMBL602943 | 1.00 | ALOX15 (0.84) | ALOX15HRH4HRH3HRH1 | |
| Maleic Acid SCHEMBL29404707 | 1.00 | ALOX15 (0.84) | ALOX15HRH4HRH3HRH1 | |
| SCHEMBL602043 | 0.93 | HRH4 (0.81) | ALOX15HRH4HRH3HRH1 | |
| Maleic Acid SCHEMBL29769889 | 0.91 | ALOX15 (1.00) | ALOX15HRH4HRH3HRH1 | |
| Jnj-7777120 SCHEMBL18486196 | 0.86 | HRH4 (0.80) | ALOX15HRH4HRH3HRH1 | |
| SCHEMBL16939347 | 0.83 | HRH4 (1.00) | ALOX15HRH4HRH3HRH1 | |
| SCHEMBL29385016 | 0.83 | HRH4 (1.00) | ALOX15HRH4HRH3HRH1 | |
| Jnj-7777120 SCHEMBL603853 | 0.82 | HRH4 (0.86) | ALOX15HRH4HRH3HRH1 | |
| Jnj-7777120 SCHEMBL603855 | 0.82 | HRH4 (0.86) | ALOX15HRH4HRH3HRH1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 4 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-20240148720-A1 | Use of Histamine Antagonists and Glucocorticoid for Treating and Preventing Neurodegenerative Diseases | CITY UNIVERSITY OF HONG KONG (HK) | 2024-05-09 | — | — | US | claimed |
| EP-2858647-B1 | H4 RECEPTOR INHIBITORS FOR TREATING TINNITUS | SENSORION (FR) | 2018-05-23 | — | — | EP | claimed |
| US-20240148720-A1 | Use of Histamine Antagonists and Glucocorticoid for Treating and Preventing Neurodegenerative Diseases | CITY UNIVERSITY OF HONG KONG (HK) | 2024-05-09 | — | — | US | disclosed |
| EP-2858647-B1 | H4 RECEPTOR INHIBITORS FOR TREATING TINNITUS | SENSORION (FR) | 2018-05-23 | — | — | EP | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (1 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20240148720-A1 | Use of Histamine Antagonists and Glucocorticoid for Treating and Preventing Neurodegenerative Diseases | HRH3, HRH4, HRH1 | HRH3 1/4885HRH1 3/4885ALOX15 572/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.