SCHEMBL18486254

SCHEMBL18486254

COc1ccc(C(OC[C@H]2O[C@@H](n3cnc4c(Sc5ccccc5)ncnc43)C[C@@H]2OP(OCCC#N)N(C(C)C)C(C)C)(c2ccccc2)c2ccc(OC)cc2)cc1

nearest known ligand 0.38

Predicted protein targets (top 4)

geneUniProtsupporting neighboursconfidence
TYMP P19971 8/20 0.38
SLC29A1 Q99808 3/20 0.35
ATG7 O95352 1/20 0.31
ADORA1 P30542 2/20 0.30

Click a target to see other patent compounds predicted against it — the reverse direction, in place.

Similar compounds — the chemically nearest patent molecules

Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.

Compoundsimilaritytop predictedshared targets
SCHEMBL18486349 0.94 TYMP (0.35) TYMPSLC29A1ATG7
SCHEMBL18486244 0.93 TYMP (0.36) TYMPSLC29A1ATG7
SCHEMBL18486344 0.93 TYMP (0.36) TYMPSLC29A1ATG7
SCHEMBL18486318 0.92 TYMP (0.37) TYMPSLC29A1
SCHEMBL18486364 0.91 TYMP (0.35) TYMPSLC29A1ATG7
SCHEMBL15301771 0.90 TYMP (0.41) TYMPADORA1
SCHEMBL18486354 0.90 TYMP (0.36) TYMPSLC29A1
SCHEMBL18486407 0.89 TYMP (0.35) TYMPSLC29A1
SCHEMBL9539565 0.89 TYMP (0.38) TYMPADORA1
SCHEMBL18486225 0.88 TYMP (0.37) TYMPSLC29A1

Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.

Patent provenance — the patents this molecule appears in, and who filed them

Claimed or disclosed in 3 patents. claimed = in the patent's claims; disclosed = body only.

PatentTitleAssigneePublishedPriorityFilingCountryStatus
US-10342819-B2 Oligonucleotide having non-natural nucleotide at 5′-terminal thereof KYOWA HAKKO KIRIN CO., LTD. (JP) 2019-07-09 US disclosed
US-20170354673-A1 OLIGONUCLEOTIDE HAVING NON-NATURAL NUCLEOTIDE AT 5'-TERMINAL THEREOF KYOWA HAKKO KIRIN CO., LTD. (JP) 2017-12-14 US disclosed
EP-3130597-A1 OLIGONUCLEOTIDE HAVING NON-NATURAL NUCLEOTIDE AT 5'-TERMINAL THEREOF Kyowa Hakko Kirin Co., Ltd. (JP) 2017-02-15 EP disclosed

Patent text — is the patent's own abstract consistent with the prediction?

For each of this compound's patents that has machine-readable text (2 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.

PatentTitleText reads most aboutPredicted target · text-rank
US-10342819-B2 Oligonucleotide having non-natural nucleotide at 5′-terminal thereof RNGTT, UPF1, NSUN3 TYMP 120/4885SLC29A1 243/4885ATG7 4813/4885
US-20170354673-A1 OLIGONUCLEOTIDE HAVING NON-NATURAL NUCLEOTIDE AT 5'-TERMINAL THEREOF RNGTT, UPF1, NSUN3 TYMP 121/4885SLC29A1 253/4885ATG7 4806/4885

“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.