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SCHEMBL18486305

SCHEMBL18486305

COc1ccc(C(OC[C@H]2O[C@@H](n3cnc4c(-c5cccc(C(=O)O)c5)ncnc43)C[C@@H]2OP(OCCC#N)N(C(C)C)C(C)C)(c2ccccc2)c2ccc(OC)cc2)cc1

nearest known ligand 0.40

Predicted protein targets (top 2)

geneUniProtsupporting neighboursconfidence
▸ DNPH1 O43598 10/20 0.40
▸ TYMP P19971 9/20 0.39

Click a target to see other patent compounds predicted against it — the reverse direction, in place.

Similar compounds — the chemically nearest patent molecules

Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.

Compoundsimilaritytop predictedshared targets
SCHEMBL19689075 0.96 DNPH1 (0.42) DNPH1TYMP
SCHEMBL18486396 0.92 TYMP (0.36) DNPH1TYMP
SCHEMBL18486233 0.91 TYMP (0.36) DNPH1TYMP
SCHEMBL19689070 0.90 TYMP (0.35) DNPH1TYMP
SCHEMBL18486244 0.90 TYMP (0.36) DNPH1TYMP
SCHEMBL19689067 0.89 TYMP (0.35) DNPH1TYMP
SCHEMBL18486210 0.89 GAPDH (0.37) TYMP
SCHEMBL19689069 0.88 TYMP (0.38) DNPH1TYMP
SCHEMBL2054229 0.88 TYMP (0.39) TYMP
SCHEMBL15786367 0.88 TYMP (0.39) TYMP

Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.

Patent provenance — the patents this molecule appears in, and who filed them

Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.

PatentTitleAssigneePublishedPriorityFilingCountryStatus
EP-3130597-A1 OLIGONUCLEOTIDE HAVING NON-NATURAL NUCLEOTIDE AT 5'-TERMINAL THEREOF Kyowa Hakko Kirin Co., Ltd. (JP) 2017-02-15 — — EP disclosed