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SCHEMBL18486397

SCHEMBL18486397

COc1ccc(C(OC[C@H]2O[C@@H](n3c(NCc4ccccc4)nc4c(C=Cc5ccccc5)ncnc43)[C@H](O[Si](C)(C)C(C)(C)C)[C@@H]2OP(OCCC#N)N(C(C)C)C(C)C)(c2ccccc2)c2ccc(OC)cc2)cc1

nearest known ligand 0.34

Predicted protein targets (top 3)

geneUniProtsupporting neighboursconfidence
▸ SLC28A2 O43868 3/20 0.34
▸ HSPA8 P11142 1/20 0.32
▸ TYMP P19971 1/20 0.30

Click a target to see other patent compounds predicted against it — the reverse direction, in place.

Similar compounds — the chemically nearest patent molecules

Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.

Compoundsimilaritytop predictedshared targets
SCHEMBL19689094 1.00 SLC28A2 (0.34) SLC28A2HSPA8TYMP
SCHEMBL18486265 0.88 TYMP (0.39) TYMP
SCHEMBL19689071 0.88 TYMP (0.39) TYMP
SCHEMBL18486381 0.88 SLC28A2 (0.32) SLC28A2
SCHEMBL18486380 0.88 SLC28A2 (0.32) SLC28A2
SCHEMBL19689082 0.87 TYMP (0.30) TYMP
SCHEMBL18486274 0.87 TYMP (0.30) TYMP
SCHEMBL17363634 0.83 TYMP (0.38) TYMP
SCHEMBL17363637 0.83 TYMP (0.38) TYMP
SCHEMBL18486253 0.81 SLC28A2 (0.32) SLC28A2

Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.

Patent provenance — the patents this molecule appears in, and who filed them

Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.

PatentTitleAssigneePublishedPriorityFilingCountryStatus
EP-3130597-B1 OLIGONUCLEOTIDE HAVING A NON-NATURAL NUCLEOTIDE AT THE 5'-TERMINAL KYOWA KIRIN CO LTD (JP) 2021-11-10 — — EP disclosed
EP-3130597-A1 OLIGONUCLEOTIDE HAVING NON-NATURAL NUCLEOTIDE AT 5'-TERMINAL THEREOF Kyowa Hakko Kirin Co., Ltd. (JP) 2017-02-15 — — EP disclosed