SCHEMBL18487296

SCHEMBL18487296

CCn1cnc(-c2cc3nccc(Oc4ccc(C(C(N)=O)C(=O)Nc5ccc(F)cc5)cc4F)c3s2)c1

nearest known ligand 0.75

Predicted protein targets (top 3)

geneUniProtsupporting neighboursconfidence
MET P08581 20/20 0.75
KDR P35968 18/20 0.75
MST1R Q04912 1/20 0.53

Click a target to see other patent compounds predicted against it — the reverse direction, in place.

Similar compounds — the chemically nearest patent molecules

Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.

Compoundsimilaritytop predictedshared targets
SCHEMBL18487294 0.94 MET (0.66) METKDRMST1R
SCHEMBL307087 0.94 MET (0.69) METKDRMST1R
SCHEMBL307609 0.94 MET (0.65) METKDRMST1R
SCHEMBL896234 0.92 MET (0.76) METKDRMST1R
SCHEMBL18487305 0.90 MET (0.65) METKDRMST1R
SCHEMBL896400 0.89 MET (0.72) METKDRMST1R
SCHEMBL307924 0.89 MET (0.73) METKDRMST1R
SCHEMBL307394 0.88 MET (0.73) METKDR
SCHEMBL18487293 0.87 MET (0.68) METKDRMST1R
SCHEMBL307273 0.86 MET (0.60) METKDRMST1R

Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.

Patent provenance — the patents this molecule appears in, and who filed them

Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.

PatentTitleAssigneePublishedPriorityFilingCountryStatus
EP-1957498-B1 INHIBITORS OF VEGF RECEPTOR AND HGF RECEPTOR SIGNALING METHYLGENE INC (CA) 2017-02-15 EP claimed
EP-1957498-B1 INHIBITORS OF VEGF RECEPTOR AND HGF RECEPTOR SIGNALING METHYLGENE INC (CA) 2017-02-15 EP disclosed