Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | MAPT | P10636 | 4/20 | 1.00 |
| ▸ | KMT2A | Q03164 | 3/20 | 1.00 |
| ▸ | MEN1 | O00255 | 2/20 | 1.00 |
| ▸ | PNLIP | P16233 | 1/20 | 1.00 |
| ▸ | POLB | P06746 | 2/20 | 0.79 |
| ▸ | XBP1 | P17861 | 2/20 | 0.79 |
| ▸ | GAA | P10253 | 2/20 | 0.79 |
| ▸ | NPSR1 | Q6W5P4 | 2/20 | 0.79 |
| ▸ | IDE | P14735 | 1/20 | 0.79 |
| ▸ | NPC1 | O15118 | 1/20 | 0.63 |
| ▸ | RAB9A | P51151 | 1/20 | 0.63 |
| ▸ | MAPK1 | P28482 | 1/20 | 0.59 |
| ▸ | ATM | Q13315 | 1/20 | 0.59 |
| ▸ | ALOX5 | P09917 | 1/20 | 0.51 |
| ▸ | PTGS1 | P23219 | 1/20 | 0.51 |
| ▸ | APP | P05067 | 2/20 | 0.42 |
| ▸ | NR1H4 | Q96RI1 | 4/20 | 0.41 |
| ▸ | BACE1 | P56817 | 1/20 | 0.41 |
| ▸ | TRPA1 | O75762 | 1/20 | 0.40 |
| ▸ | LDHA | P00338 | 1/20 | 0.40 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| Mahanimbine SCHEMBL2991765 | 1.00 | MAPT (1.00) | MAPTKMT2AMEN1PNLIPPOLB | |
| Mahanimbine SCHEMBL18488203 | 1.00 | MAPT (1.00) | MAPTKMT2AMEN1PNLIPPOLB | |
| SCHEMBL20434657 | 0.89 | MAPT (0.84) | MAPTKMT2AMEN1PNLIPPOLB | |
| SCHEMBL13142229 | 0.88 | MAPT (1.00) | MAPTKMT2AMEN1PNLIPPOLB | |
| SCHEMBL18317471 | 0.88 | MAPT (1.00) | MAPTKMT2AMEN1PNLIPPOLB | |
| SCHEMBL13344164 | 0.88 | MAPT (1.00) | MAPTKMT2AMEN1PNLIPPOLB | |
| SCHEMBL31723092 | 0.86 | MAPT (0.73) | MAPTKMT2AMEN1PNLIPPOLB | |
| SCHEMBL31723084 | 0.81 | MAPT (0.71) | MAPTKMT2AMEN1PNLIPPOLB | |
| SCHEMBL25937950 | 0.80 | MAPT (0.72) | MAPTKMT2AMEN1PNLIPPOLB | |
| SCHEMBL30366382 | 0.79 | KMT2A (0.66) | MAPTKMT2AMEN1PNLIPPOLB |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 6 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-20200247751-A1 | SMALL MOLECULE ANDROGEN RECEPTOR INHIBITORS AND METHODS OF USE THEREOF | GEORGETOWN UNIVERSITY (US) | 2020-08-06 | — | — | US | disclosed |
| US-20190077755-A1 | SMALL MOLECULE ANDROGEN RECEPTOR INHIBITORS AND METHODS OF USE THEREOF | GEORGETOWN UNIVERSITY (US) | 2019-03-14 | — | — | US | disclosed |
| US-10173978-B2 | Small molecule androgen receptor inhibitors and methods of use thereof | GEORGETOWN UNIVERSITY (US) | 2019-01-08 | — | — | US | disclosed |
| US-20180215712-A1 | SMALL MOLECULE ANDROGEN RECEPTOR INHIBITORS AND METHODS OF USE THEREOF | GEORGETOWN UNIVERSITY (US) | 2018-08-02 | — | — | US | disclosed |
| US-20180215712-A1 | SMALL MOLECULE ANDROGEN RECEPTOR INHIBITORS AND METHODS OF USE THEREOF | GEORGETOWN UNIVERSITY (US) | 2018-08-02 | — | — | US | disclosed |
| WO-2017023916-A1 | SMALL MOLECULE ANDROGEN RECEPTOR INHIBITORS AND METHODS OF USE THEREOF | GEORGETOWN UNIVERSITY (US) | 2017-02-09 | — | — | WO | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (4 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20180215712-A1 | SMALL MOLECULE ANDROGEN RECEPTOR INHIBITORS AND METHODS OF USE THEREOF | AR, KLK3, BRDT | MAPT 3890/4885KMT2A 1054/4885MEN1 3004/4885 |
| US-20190077755-A1 | SMALL MOLECULE ANDROGEN RECEPTOR INHIBITORS AND METHODS OF USE THEREOF | AR, KLK3, BRDT | MAPT 3890/4885KMT2A 1054/4885MEN1 3004/4885 |
| US-20200247751-A1 | SMALL MOLECULE ANDROGEN RECEPTOR INHIBITORS AND METHODS OF USE THEREOF | AR, KLK3, BRDT | MAPT 3890/4885KMT2A 1054/4885MEN1 3004/4885 |
| US-10173978-B2 | Small molecule androgen receptor inhibitors and methods of use thereof | AR, KLK3, BRDT | MAPT 3890/4885KMT2A 1054/4885MEN1 3004/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.