Mahanimbine

Mahanimbine

SCHEMBL2991765

CC(C)=CCCC1(C)C=Cc2c(c(C)cc3c2[nH]c2ccccc23)O1

nearest known ligand 1.00 ✓ in ChEMBL — recovers established targets

Full drug profile on Sugi Atlas →

Predicted protein targets (top 20)

geneUniProtsupporting neighboursconfidence
▸ MAPT P10636 4/20 1.00
▸ KMT2A Q03164 3/20 1.00
▸ MEN1 O00255 2/20 1.00
▸ PNLIP P16233 1/20 1.00
▸ POLB P06746 2/20 0.79
▸ XBP1 P17861 2/20 0.79
▸ GAA P10253 2/20 0.79
▸ NPSR1 Q6W5P4 2/20 0.79
▸ IDE P14735 1/20 0.79
▸ NPC1 O15118 1/20 0.63
▸ RAB9A P51151 1/20 0.63
▸ MAPK1 P28482 1/20 0.59
▸ ATM Q13315 1/20 0.59
▸ ALOX5 P09917 1/20 0.51
▸ PTGS1 P23219 1/20 0.51
▸ APP P05067 2/20 0.42
▸ NR1H4 Q96RI1 4/20 0.41
▸ BACE1 P56817 1/20 0.41
▸ TRPA1 O75762 1/20 0.40
▸ LDHA P00338 1/20 0.40

Click a target to see other patent compounds predicted against it — the reverse direction, in place.

Similar compounds — the chemically nearest patent molecules

Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.

Compoundsimilaritytop predictedshared targets
Mahanimbine SCHEMBL18488200 1.00 MAPT (1.00) MAPTKMT2AMEN1PNLIPPOLB
Mahanimbine SCHEMBL18488203 1.00 MAPT (1.00) MAPTKMT2AMEN1PNLIPPOLB
SCHEMBL20434657 0.89 MAPT (0.84) MAPTKMT2AMEN1PNLIPPOLB
SCHEMBL13142229 0.88 MAPT (1.00) MAPTKMT2AMEN1PNLIPPOLB
SCHEMBL18317471 0.88 MAPT (1.00) MAPTKMT2AMEN1PNLIPPOLB
SCHEMBL13344164 0.88 MAPT (1.00) MAPTKMT2AMEN1PNLIPPOLB
SCHEMBL31723092 0.86 MAPT (0.73) MAPTKMT2AMEN1PNLIPPOLB
SCHEMBL31723084 0.81 MAPT (0.71) MAPTKMT2AMEN1PNLIPPOLB
SCHEMBL25937950 0.80 MAPT (0.72) MAPTKMT2AMEN1PNLIPPOLB
SCHEMBL30366382 0.79 KMT2A (0.66) MAPTKMT2AMEN1PNLIPPOLB

Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.

Patent provenance — the patents this molecule appears in, and who filed them

Claimed or disclosed in 57 patents — showing the first 20. claimed = in the patent's claims; disclosed = body only.

PatentTitleAssigneePublishedPriorityFilingCountryStatus
EP-4647073-A1 MURRAYA KOENIGII IN THE TREATMENT OF UPPER RESPIRATORY TRACT INFECTIONS Nutraceutical Technology Pharma Biotech S.r.l. (IT) 2025-11-12 — — EP claimed
US-20220143124-A1 SYNERGISTIC HERBAL COMPOSITIONS FOR PREVENTION, TREATMENT OR CONTROL OF PAIN AND/OR CARTILAGE REGENERATION LAILA NUTRACEUTICALS (IN) 2022-05-12 — — US claimed
WO-2020202211-A1 SYNERGISTIC HERBAL COMPOSITIONS FOR PREVENTION, TREATMENT OR CONTROL OF PAIN AND/OR CARTILAGE REGENERATION LAILA NUTRACEUTICALS (IN) 2020-10-08 — — WO claimed
US-20180296490-A1 BIOACTIVE DELIVERY VEHICLES THE REGENTS OF THE UNIVERSITY OF CALIFORNIA (US) 2018-10-18 — — US claimed
EP-3212159-A1 BIOACTIVE DELIVERY VEHICLES The Regents of the University of California (US) 2017-09-06 — — EP claimed
WO-2016069740-A1 BIOACTIVE DELIVERY VEHICLES THE REGENTS OF THE UNIVERSITY OF CALIFORNIA (US) 2016-05-06 — — WO claimed
US-20150050371-A1 Extract Formulations of Rhodamnia Cinerea And Uses Thereof BIOTROPICS MALAYSIA BERHAD (MY) 2015-02-19 — — US claimed
US-8637679-B2 Process for the isolation of organic compounds useful for the treatment of cancer COUNCIL OF SCIENTIFIC AND INDUSTRIAL RESEARCH (IN) 2014-01-28 — — US claimed
US-8541383-B2 Synergistic phytochemical composition for the treatment of obesity Laila Nutraceurticals (IN) 2013-09-24 — — US claimed
WO-2013133685-A1 EXTRACT FORMULATIONS OF RHODAMNIA CINEREA AND USES THEREOF BIOTROPICS MALAYSIA BERHAD (MY) 2013-09-12 — — WO claimed
US-20130065932-A1 PROCESS FOR THE ISOLATION OF ORGANIC COMPOUNDS USEFUL FOR THE TREATMENT OF CANCER COUNCIL OF SCIENTIFIC AND INDUSTRIAL RESEARCH (IN) 2013-03-14 — — US claimed
US-20100227828-A1 NEW SYNERGISTIC PHYTOCHEMICAL COMPOSITION FOR THE TREATMENT OF OBESITY LAILA NUTRACEUTICALS (IN) 2010-09-09 — — US claimed
EP-4647073-A1 MURRAYA KOENIGII IN THE TREATMENT OF UPPER RESPIRATORY TRACT INFECTIONS Nutraceutical Technology Pharma Biotech S.r.l. (IT) 2025-11-12 — — EP disclosed
EP-4099976-B1 MURRAYA KOENIGII EXTRACT AND USE THEREOF IN COSMETICS GATTEFOSSE SAS (FR) 2024-12-04 — — EP disclosed
WO-2024189607-A1 METHODS AND BIOAVAILABLE HIGHLY PERMEABLE COMPOUNDS FOR DISEASES TREATMENT DIDENKO KIRILL (MX) 2024-09-19 — — WO disclosed
CN-118141926-A Application of plant carbazole alkaloid in preparation of iron death inhibitor 北京大学 2024-06-07 — — CN disclosed
US-20060216251-A1 Topical formulations and methods of use TRACIE MARTYN INTERNATIONAL, LLC (US) 2006-09-28 — — US disclosed
US-6989165-B2 Synergistic composition for treating hyperilipdemia COUNCIL OF SCIENTIFIC AND INDUSTRIAL RESEARCH (IN) 2006-01-24 — — US disclosed
WO-2005070442-A1 A SYNERGISTIC COMPOSITION FOR TREATING HYPERLIPIDEMIA COUNCIL OF SCIENTIFIC & INDUSTRIAL RESEARCH (IN) 2005-08-04 — — WO disclosed
US-20050136138-A1 Synergistic composition for treating hyperilipdemia COUNCIL OF SCIENTIFIC AND INDUSTRIAL RESEARCH (IN) 2005-06-23 — — US disclosed

Patent text — is the patent's own abstract consistent with the prediction?

For each of this compound's patents that has machine-readable text (4 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.

PatentTitleText reads most aboutPredicted target · text-rank
US-20130065932-A1 PROCESS FOR THE ISOLATION OF ORGANIC COMPOUNDS USEFUL FOR THE TREATMENT OF CANCER PSMG3, HSP90B1, HSPA1A MAPT 1704/4885KMT2A 356/4885MEN1 3075/4885
US-20220143124-A1 SYNERGISTIC HERBAL COMPOSITIONS FOR PREVENTION, TREATMENT OR CONTROL OF PAIN AND/OR CARTILAGE REGENERATION TNF, COL2A1, ALPI MAPT 3513/4885KMT2A 911/4885MEN1 3864/4885
US-20060216251-A1 Topical formulations and methods of use CPT1B, SLC25A20, CPT1A MAPT 2476/4885KMT2A 2610/4885MEN1 2963/4885
US-20100227828-A1 NEW SYNERGISTIC PHYTOCHEMICAL COMPOSITION FOR THE TREATMENT OF OBESITY BMI1, FABP4, LIPC MAPT 4730/4885KMT2A 63/4885MEN1 3040/4885

“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.

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