SCHEMBL18488353

SCHEMBL18488353

CCOC(=O)c1nc2ccc(Br)cc2c(C)c1C

nearest known ligand 0.62

Predicted protein targets (top 20)

geneUniProtsupporting neighboursconfidence
ALDH1A1 P00352 4/20 0.62
SMN1; SMN2 Q16637 3/20 0.62
ATM Q13315 2/20 0.53
MAPT P10636 1/20 0.53
ELANE P08246 4/20 0.52
MAPK1 P28482 1/20 0.47
TARBP2 Q15633 1/20 0.47
GAA P10253 2/20 0.46
RXFP1 Q9HBX9 2/20 0.46
NPSR1 Q6W5P4 1/20 0.46
GABRA1 P14867 1/20 0.45
GABRB1 P18505 1/20 0.45
GABRA3 P34903 1/20 0.45
GABRB2 P47870 1/20 0.45
KDM4E B2RXH2 1/20 0.45
L3MBTL1 Q9Y468 1/20 0.45
SIRT2 Q8IXJ6 1/20 0.44
HTT P42858 2/20 0.44
MEN1 O00255 1/20 0.44
PRNP P04156 1/20 0.44

Click a target to see other patent compounds predicted against it — the reverse direction, in place.

Similar compounds — the chemically nearest patent molecules

Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.

Compoundsimilaritytop predictedshared targets
SCHEMBL18449792 0.84 ALDH1A1 (0.60) ALDH1A1SMN1; SMN2ATMMAPTELANE
SCHEMBL13107065 0.83 ATM (0.57) ALDH1A1SMN1; SMN2ATMMAPTELANE
SCHEMBL31442611 0.82 ALDH1A1 (0.61) ALDH1A1SMN1; SMN2ATMMAPTELANE
SCHEMBL29267710 0.82 ALDH1A1 (0.57) ALDH1A1SMN1; SMN2ATMMAPTELANE
SCHEMBL3101136 0.81 ALDH1A1 (0.51) ALDH1A1SMN1; SMN2ATMMAPTELANE
SCHEMBL2004025 0.79 ALDH1A1 (0.53) ALDH1A1SMN1; SMN2ATMMAPTELANE
SCHEMBL2000832 0.78 SMN1; SMN2 (0.62) ALDH1A1SMN1; SMN2ATMMAPTELANE
SCHEMBL1999627 0.78 ALDH1A1 (0.78) ALDH1A1SMN1; SMN2ATMMAPTELANE
SCHEMBL30165401 0.78 ALDH1A1 (0.52) ALDH1A1SMN1; SMN2ATMMAPTELANE
SCHEMBL5810083 0.78 ATM (0.79) ALDH1A1SMN1; SMN2ATMMAPTELANE

Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.

Patent provenance — the patents this molecule appears in, and who filed them

Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.

PatentTitleAssigneePublishedPriorityFilingCountryStatus
WO-2017023905-A1 HETEROCYCLIC COMPOUNDS USEFUL AS MODULATORS OF TNF ALPHA BRISTOL-MYERS SQUIBB COMPANY (US) 2017-02-09 WO disclosed