Known targets — ChEMBL curated mechanism
The experimentally established mechanism targets of Almotriptan. The predicted profile below is derived independently by chemical similarity — agreement is a validation signal, a miss is honest.
Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | HTR1B known ✓ | P28222 | 5/20 | 0.57 |
| ▸ | HTR1D known ✓ | P28221 | 5/20 | 0.57 |
| ▸ | HTR1F known ✓ | P30939 | 1/20 | 0.57 |
| ▸ | HTR1A | P08908 | 7/20 | 0.85 |
| ▸ | HTR2A | P28223 | 4/20 | 0.85 |
| ▸ | HTR2B | P41595 | 3/20 | 0.85 |
| ▸ | ADRA2B | P18089 | 2/20 | 0.85 |
| ▸ | LMNA | P02545 | 1/20 | 0.85 |
| ▸ | KCNH2 | Q12809 | 1/20 | 0.85 |
| ▸ | HTR5A | P47898 | 10/20 | 0.57 |
| ▸ | HTR2C | P28335 | 2/20 | 0.57 |
| ▸ | HTR7 | P34969 | 2/20 | 0.57 |
| ▸ | HTR1E | P28566 | 1/20 | 0.57 |
| ▸ | HTR3A | P46098 | 1/20 | 0.57 |
| ▸ | SLC47A1 | Q96FL8 | 1/20 | 0.57 |
| ▸ | ADRA1A | P35348 | 2/20 | 0.55 |
| ▸ | ADRA2A | P08913 | 1/20 | 0.55 |
| ▸ | ADRA2C | P18825 | 1/20 | 0.55 |
| ▸ | MAOA | P21397 | 1/20 | 0.55 |
| ▸ | ADRA1D | P25100 | 1/20 | 0.55 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| Almotriptan SCHEMBL221132 | 1.00 | HTR1A (0.85) | HTR1AHTR2AHTR2BADRA2BLMNA | |
| Almotriptan SCHEMBL2259962 | 1.00 | HTR1A (0.85) | HTR1AHTR2AHTR2BADRA2BLMNA | |
| Almotriptan SCHEMBL1774275 | 0.93 | HTR1A (0.90) | HTR1AHTR2AHTR2BADRA2BLMNA | |
| Almotriptan SCHEMBL1957 | 0.92 | HTR1A (1.00) | HTR1AHTR2AHTR2BADRA2BLMNA | |
| Almotriptan SCHEMBL29396422 | 0.92 | HTR1A (1.00) | HTR1AHTR2AHTR2BADRA2BLMNA | |
| Almotriptan SCHEMBL3273179 | 0.92 | HTR1A (1.00) | HTR1AHTR2AHTR2BADRA2BLMNA | |
| Almotriptan SCHEMBL2761861 | 0.91 | HTR1A (0.86) | HTR1AHTR2AHTR2BADRA2BLMNA | |
| SCHEMBL1437 | 0.91 | HTR1A (0.98) | HTR1AHTR2AHTR2BADRA2BLMNA | |
| Almotriptan SCHEMBL2166 | 0.91 | HTR1A (0.98) | HTR1AHTR2AHTR2BADRA2BLMNA | |
| Almotriptan SCHEMBL5042399 | 0.90 | HTR1A (0.96) | HTR1AHTR2AHTR2BADRA2BLMNA |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 6 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| WO-2012085723-A1 | A PROCESS FOR THE PURIFICATION OF ALMOTRIPTAN ACID ADDITION SALT | ORCHID CHEMICALS AND PHARMACEUTICALS LIMITED (IN) | 2012-06-28 | — | — | WO | claimed |
| WO-2012085723-A1 | A PROCESS FOR THE PURIFICATION OF ALMOTRIPTAN ACID ADDITION SALT | ORCHID CHEMICALS AND PHARMACEUTICALS LIMITED (IN) | 2012-06-28 | — | — | WO | disclosed |
| EP-2158197-B1 | METHOD FOR THE PREPARATION OF HIGH PURITY ALMOTRIPTAN | ZENTIVA KS (CZ) | 2011-05-25 | — | — | EP | disclosed |
| WO-2010113183-A2 | PROCESS FOR THE PREPARATION OF 1-[[[3-[2-(DIMETHYLAMINO)ETHYL]-1H-INDOL-5-YL]METHYL]SULFONYL] PYRROLIDINE AND ITS PHARMACEUTICALLY ACCEPTABLE SALTS | MSN LABORATORIES LIMITED (IN) | 2010-10-07 | — | — | WO | disclosed |
| EP-2158197-A1 | METHOD FOR THE PREPARATION OF HIGH PURITY ALMOTRIPTAN | Zentiva, k.s. (CZ) | 2010-03-03 | — | — | EP | disclosed |
| WO-2008151584-A1 | METHOD FOR THE PREPARATION OF HIGH PURITY ALMOTRIPTAN | ZENTIVA, A.S. (CZ) | 2008-12-18 | — | — | WO | disclosed |