SCHEMBL18489495

SCHEMBL18489495

CC(C)c1ccc(O)c(C=Nc2ccccc2)c1

nearest known ligand 0.50

Predicted protein targets (top 20)

geneUniProtsupporting neighboursconfidence
SIRT2 Q8IXJ6 1/20 0.50
MAOB P27338 6/20 0.46
MAOA P21397 1/20 0.46
ALDH1A1 P00352 2/20 0.46
MAPT P10636 2/20 0.46
KDM4E B2RXH2 1/20 0.46
CA1 P00915 1/20 0.44
CA2 P00918 1/20 0.44
TSHR P16473 1/20 0.43
LMNA P02545 1/20 0.43
SMN1; SMN2 Q16637 1/20 0.43
FNTA P49354 1/20 0.43
FNTB P49356 1/20 0.43
CYP1A2 P05177 1/20 0.43
CYP3A4 P08684 1/20 0.43
CYP2D6 P10635 1/20 0.43
THRB P10828 1/20 0.43
CYP2C9 P11712 1/20 0.43
PKM P14618 1/20 0.43
ALOX15 P16050 1/20 0.43

Click a target to see other patent compounds predicted against it — the reverse direction, in place.

Similar compounds — the chemically nearest patent molecules

Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.

Compoundsimilaritytop predictedshared targets
SCHEMBL18489494 1.00 SIRT2 (0.50) SIRT2MAOBMAOAALDH1A1MAPT
Acetic Acid SCHEMBL1229734 0.82 CA2 (0.46) SIRT2ALDH1A1MAPTKDM4ECA1
Acetic Acid SCHEMBL1229478 0.82 EGFR (0.41) ALDH1A1MAPTKDM4ECA1CA2
SCHEMBL18489514 0.79 MAPT (0.44) ALDH1A1MAPTKDM4ECA1CA2
SCHEMBL18489516 0.79 MAPT (0.44) ALDH1A1MAPTKDM4ECA1CA2
SCHEMBL12767303 0.79 MAOB (0.67) SIRT2MAOBMAOAALDH1A1MAPT
SCHEMBL18489536 0.79 MAOB (0.67) SIRT2MAOBMAOAALDH1A1MAPT
Acetic Acid SCHEMBL1229822 0.79 CA12 (0.47) ALDH1A1MAPTKDM4ECA2LMNA
SCHEMBL19320484 0.78 TYR (0.49) ALDH1A1MAPTKDM4ECA1CA2
SCHEMBL11405305 0.78 MAOB (0.67) SIRT2MAOBMAOAALDH1A1TSHR

Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.

Patent provenance — the patents this molecule appears in, and who filed them

Claimed or disclosed in 9 patents. claimed = in the patent's claims; disclosed = body only.

PatentTitleAssigneePublishedPriorityFilingCountryStatus
EP-3135699-B1 CATALYST COMPONENT FOR PROPYLENE POLYMERIZATION, PREPARATION METHOD THEREFOR AND CATALYST HAVING SAME CHINA PETROLEUM & CHEM CORP (CN) 2021-07-21 EP claimed
US-10184017-B2 Catalyst component for propene polymerization, preparation method thereof, and catalyst containing the same CHINA PETROLEUM & CHEMICAL CORPORATION (CN) 2019-01-22 US claimed
CN-105085732-B A kind of catalytic component and its catalyst for olefinic polymerization 中国石油化工股份有限公司 2017-11-07 CN claimed
EP-3135699-A1 CATALYST COMPONENT FOR PROPYLENE POLYMERIZATION, PREPARATION METHOD THEREFOR AND CATALYST HAVING SAME China Petroleum & Chemical Corporation (CN) 2017-03-01 EP claimed
US-20170044280-A1 Catalyst Component for Propene Polymerization, Preparation Method Thereof, and Catalyst Containing the Same CHINA PETROLEUM & CHEMICAL CORPORATION (CN) 2017-02-16 US claimed
EP-3135699-B1 CATALYST COMPONENT FOR PROPYLENE POLYMERIZATION, PREPARATION METHOD THEREFOR AND CATALYST HAVING SAME CHINA PETROLEUM & CHEM CORP (CN) 2021-07-21 EP disclosed
US-10184017-B2 Catalyst component for propene polymerization, preparation method thereof, and catalyst containing the same CHINA PETROLEUM & CHEMICAL CORPORATION (CN) 2019-01-22 US disclosed
EP-3135699-A1 CATALYST COMPONENT FOR PROPYLENE POLYMERIZATION, PREPARATION METHOD THEREFOR AND CATALYST HAVING SAME China Petroleum & Chemical Corporation (CN) 2017-03-01 EP disclosed
US-20170044280-A1 Catalyst Component for Propene Polymerization, Preparation Method Thereof, and Catalyst Containing the Same CHINA PETROLEUM & CHEMICAL CORPORATION (CN) 2017-02-16 US disclosed