Predicted protein targets (top 10)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | NOTUM | Q6P988 | 1/20 | 0.38 |
| ▸ | GCK | P35557 | 13/20 | 0.35 |
| ▸ | KCNH2 | Q12809 | 6/20 | 0.35 |
| ▸ | IDO1 | P14902 | 3/20 | 0.34 |
| ▸ | NPC1 | O15118 | 2/20 | 0.33 |
| ▸ | RAB9A | P51151 | 2/20 | 0.33 |
| ▸ | SMN1; SMN2 | Q16637 | 2/20 | 0.33 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.33 |
| ▸ | LMNA | P02545 | 1/20 | 0.33 |
| ▸ | MAPT | P10636 | 1/20 | 0.33 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL839153 | 0.87 | GCK (0.43) | NOTUMGCKKCNH2IDO1 | |
| SCHEMBL839825 | 0.87 | GCK (0.43) | NOTUMGCKKCNH2IDO1 | |
| SCHEMBL839154 | 0.87 | GCK (0.43) | NOTUMGCKKCNH2IDO1 | |
| SCHEMBL1848056 | 0.85 | RAB9A (0.45) | NPC1RAB9ASMN1; SMN2ALDH1A1MAPT | |
| SCHEMBL838004 | 0.84 | GCK (0.45) | NOTUMGCKKCNH2IDO1NPC1 | |
| SCHEMBL838003 | 0.84 | GCK (0.45) | NOTUMGCKKCNH2IDO1NPC1 | |
| SCHEMBL839004 | 0.84 | NOTUM (0.38) | NOTUMGCKKCNH2IDO1 | |
| SCHEMBL839005 | 0.84 | NOTUM (0.38) | NOTUMGCKKCNH2IDO1 | |
| SCHEMBL839537 | 0.82 | NOTUM (0.40) | NOTUMGCKKCNH2IDO1 | |
| SCHEMBL839536 | 0.82 | NOTUM (0.40) | NOTUMGCKKCNH2IDO1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-2324028-A2 | THERAPEUTIC AGENTS 414 | AstraZeneca AB (SE) | 2011-05-25 | — | — | EP | disclosed |
| WO-2010015849-A2 | THERAPEUTIC AGENTS 414 | ASTRAZENECA AB (SE) | 2010-02-11 | — | — | WO | disclosed |