Predicted protein targets (top 7)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | NOTUM | Q6P988 | 1/20 | 0.40 |
| ▸ | GCK | P35557 | 10/20 | 0.37 |
| ▸ | KCNH2 | Q12809 | 6/20 | 0.37 |
| ▸ | IDO1 | P14902 | 2/20 | 0.35 |
| ▸ | ABL1 | P00519 | 2/20 | 0.35 |
| ▸ | CHEK1 | O14757 | 2/20 | 0.35 |
| ▸ | GRM5 | P41594 | 2/20 | 0.34 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL839537 | 1.00 | NOTUM (0.40) | NOTUMGCKKCNH2IDO1ABL1 | |
| SCHEMBL839100 | 0.84 | GCK (0.45) | NOTUMGCKKCNH2IDO1ABL1 | |
| SCHEMBL839101 | 0.84 | GCK (0.45) | NOTUMGCKKCNH2IDO1ABL1 | |
| SCHEMBL839058 | 0.84 | NOTUM (0.45) | NOTUMGCKKCNH2IDO1ABL1 | |
| SCHEMBL839059 | 0.84 | NOTUM (0.45) | NOTUMGCKKCNH2IDO1ABL1 | |
| SCHEMBL839154 | 0.82 | GCK (0.43) | NOTUMGCKKCNH2IDO1ABL1 | |
| SCHEMBL839825 | 0.82 | GCK (0.43) | NOTUMGCKKCNH2IDO1ABL1 | |
| SCHEMBL839153 | 0.82 | GCK (0.43) | NOTUMGCKKCNH2IDO1ABL1 | |
| SCHEMBL1848972 | 0.82 | NOTUM (0.38) | NOTUMGCKKCNH2IDO1 | |
| SCHEMBL838003 | 0.82 | GCK (0.45) | NOTUMGCKKCNH2IDO1ABL1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 4 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-8143263-B2 | Therapeutic agents | ASTRAZENECA AB (SE) | 2012-03-27 | — | — | US | disclosed |
| EP-2324028-A2 | THERAPEUTIC AGENTS 414 | AstraZeneca AB (SE) | 2011-05-25 | — | — | EP | disclosed |
| US-20100093757-A1 | THERAPEUTIC AGENTS 414 | ASTRAZENECA AB (SE) | 2010-04-15 | — | — | US | disclosed |
| WO-2010015849-A2 | THERAPEUTIC AGENTS 414 | ASTRAZENECA AB (SE) | 2010-02-11 | — | — | WO | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (1 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20100093757-A1 | THERAPEUTIC AGENTS 414 | GCK, GCKR, GPR119 | NOTUM 1194/4885GCK 1/4885KCNH2 1438/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.