Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | TMEM97 | Q5BJF2 | 1/20 | 0.52 |
| ▸ | SIGMAR1 | Q99720 | 1/20 | 0.52 |
| ▸ | KDM4E | B2RXH2 | 3/20 | 0.49 |
| ▸ | LMNA | P02545 | 3/20 | 0.49 |
| ▸ | ALOX15 | P16050 | 3/20 | 0.49 |
| ▸ | NPC1 | O15118 | 1/20 | 0.49 |
| ▸ | HTT | P42858 | 1/20 | 0.49 |
| ▸ | RAB9A | P51151 | 1/20 | 0.49 |
| ▸ | MAP4K4 | O95819 | 5/20 | 0.49 |
| ▸ | PIM1 | P11309 | 5/20 | 0.49 |
| ▸ | PRKACA | P17612 | 5/20 | 0.49 |
| ▸ | GSK3B | P49841 | 5/20 | 0.49 |
| ▸ | CLK4 | Q9HAZ1 | 5/20 | 0.49 |
| ▸ | CLK2 | P49760 | 4/20 | 0.49 |
| ▸ | CDK5 | Q00535 | 4/20 | 0.49 |
| ▸ | DYRK1A | Q13627 | 4/20 | 0.49 |
| ▸ | HIPK2 | Q9H2X6 | 4/20 | 0.49 |
| ▸ | CHEK1 | O14757 | 3/20 | 0.49 |
| ▸ | PRKAA1 | Q13131 | 3/20 | 0.49 |
| ▸ | ROCK1 | Q13464 | 3/20 | 0.49 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL3231370 | 0.85 | CDK2 (0.59) | TMEM97SIGMAR1KDM4ELMNAALOX15 | |
| SCHEMBL1850842 | 0.81 | CHEK1 (0.66) | TMEM97SIGMAR1LMNAMAP4K4PIM1 | |
| SCHEMBL3600611 | 0.78 | CHEK1 (0.66) | TMEM97SIGMAR1LMNAMAP4K4PIM1 | |
| SCHEMBL2064431 | 0.77 | SLC6A4 (0.64) | TMEM97SIGMAR1KDM4ELMNAALOX15 | |
| SCHEMBL13064304 | 0.74 | TMEM97 (0.59) | TMEM97SIGMAR1KDM4ELMNAALOX15 | |
| SCHEMBL13502652 | 0.74 | SIGMAR1 (0.68) | TMEM97SIGMAR1KDM4ELMNAALOX15 | |
| SCHEMBL18324727 | 0.72 | TDO2 (0.67) | TMEM97SIGMAR1MAP4K4PIM1PRKACA | |
| SCHEMBL18324729 | 0.72 | CHEK1 (0.63) | TMEM97SIGMAR1LMNAMAP4K4PIM1 | |
| SCHEMBL18129469 | 0.71 | CHEK1 (0.62) | TMEM97SIGMAR1MAP4K4PIM1PRKACA | |
| SCHEMBL1853760 | 0.71 | CHEK1 (0.62) | TMEM97SIGMAR1LMNAMAP4K4PIM1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-2323659-A1 | COMPOUNDS USEFUL AS INHIBITORS OF PROTEIN KINASES | Abbott Laboratories (US) | 2011-05-25 | — | — | EP | disclosed |
| WO-2010017150-A1 | COMPOUNDS USEFUL AS INHIBITORS OF PROTEIN KINASES | ABBOTT LABORATORIES (US) | 2010-02-11 | — | — | WO | disclosed |