Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | TOP1 | P11387 | 8/20 | 0.45 |
| ▸ | KDM4E | B2RXH2 | 4/20 | 0.43 |
| ▸ | SMN1; SMN2 | Q16637 | 3/20 | 0.43 |
| ▸ | LMNA | P02545 | 2/20 | 0.43 |
| ▸ | MAPT | P10636 | 2/20 | 0.43 |
| ▸ | TDP1 | Q9NUW8 | 2/20 | 0.43 |
| ▸ | GMNN | O75496 | 1/20 | 0.43 |
| ▸ | TP53 | P04637 | 1/20 | 0.43 |
| ▸ | HSP90AA1 | P07900 | 1/20 | 0.43 |
| ▸ | MMP2 | P08253 | 1/20 | 0.43 |
| ▸ | CYP3A4 | P08684 | 1/20 | 0.43 |
| ▸ | CYP2D6 | P10635 | 1/20 | 0.43 |
| ▸ | MMP9 | P14780 | 1/20 | 0.43 |
| ▸ | ALOX15 | P16050 | 1/20 | 0.43 |
| ▸ | TSHR | P16473 | 1/20 | 0.43 |
| ▸ | NFKB1 | P19838 | 1/20 | 0.43 |
| ▸ | MMP8 | P22894 | 1/20 | 0.43 |
| ▸ | CCR1 | P32246 | 1/20 | 0.43 |
| ▸ | THPO | P40225 | 1/20 | 0.43 |
| ▸ | MTOR | P42345 | 1/20 | 0.43 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL1180188 | 0.73 | NPC1 (0.47) | KDM4ESMN1; SMN2LMNAMAPTTDP1 | |
| SCHEMBL2653390 | 0.73 | TSHR (0.52) | KDM4ESMN1; SMN2LMNAMAPTTDP1 | |
| SCHEMBL17967674 | 0.73 | PDE5A (0.41) | KDM4EMAPTALDH1A1GAAAXL | |
| SCHEMBL16060478 | 0.73 | TOP1 (0.44) | TOP1KDM4ESMN1; SMN2LMNAMAPT | |
| SCHEMBL9864565 | 0.69 | LMNA (0.52) | KDM4ESMN1; SMN2LMNAMAPTTDP1 | |
| SCHEMBL9678802 | 0.69 | CCR1 (0.47) | KDM4ESMN1; SMN2LMNAMAPTTDP1 | |
| SCHEMBL12603044 | 0.68 | CDK1 (0.66) | KDM4ESMN1; SMN2LMNAMAPTTP53 | |
| SCHEMBL675654 | 0.68 | NPC1 (0.44) | KDM4ENPC1GBA1ALDH1A1RAB9A | |
| SCHEMBL473716 | 0.68 | KDM4C (0.45) | MAPTNPC1GBA1 | |
| SCHEMBL3417389 | 0.68 | NPC1 (0.40) | KDM4ESMN1; SMN2MAPTHTTNPC1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 15 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| CN-117777117-A | Organic luminescent material and application thereof | 武汉尚赛光电科技有限公司 | 2024-03-29 | — | — | CN | disclosed |
| CN-112500397-B | Organic electroluminescent material with dibenzofuran-connected anthracene core structure and preparation method and device thereof | 武汉尚赛光电科技有限公司 | 2022-11-11 | — | — | CN | disclosed |
| CN-112500397-A | Organic electroluminescent material with dibenzofuran-connected anthracene core structure and preparation method and device thereof | 武汉尚赛光电科技有限公司 | 2021-03-16 | — | — | CN | disclosed |
| US-20150368244-A1 | DIAZACARBAZOLES AND METHODS OF USE | GENENTECH, INC. (US) | 2015-12-24 | — | — | US | disclosed |
| US-20150368244-A1 | DIAZACARBAZOLES AND METHODS OF USE | GENENTECH, INC. (US) | 2015-12-24 | — | — | US | disclosed |
| JP-2014196309-A | DIAZACARBAZOLES AND METHODS OF USE | ジェネンテック， インコーポレイテッド | 2014-10-16 | — | — | JP | disclosed |
| CN-102119162-B | Diazacarbazoles and methods of use | GENENTECH, INC. (US) | 2014-10-08 | — | — | CN | disclosed |
| EP-2324024-B1 | DIAZACARBAZOLES AND METHODS OF USE | GENENTECH INC (US) | 2012-09-26 | — | — | EP | disclosed |
| CN-102119162-A | Diazacarbazoles and methods of use | GENENTECH INC | 2011-07-06 | — | — | CN | disclosed |
| US-20110124654-A1 | DIAZACARBAZOLES AND METHODS OF USE | ARGENTA DISCOVERY 2009 LIMITED (GB) | 2011-05-26 | — | — | US | disclosed |
| US-20110124654-A1 | DIAZACARBAZOLES AND METHODS OF USE | ARGENTA DISCOVERY 2009 LIMITED (GB) | 2011-05-26 | — | — | US | disclosed |
| EP-2324024-A1 | DIAZACARBAZOLES AND METHODS OF USE | Genentech, Inc. (US) | 2011-05-25 | — | — | EP | disclosed |
| EP-2324024-A1 | DIAZACARBAZOLES AND METHODS OF USE | Genentech, Inc. (US) | 2011-05-25 | — | — | EP | disclosed |
| WO-2009151589-A1 | DIAZACARBAZOLES AND METHODS OF USE | GENENTECH, INC. (US) | 2009-12-17 | — | — | WO | disclosed |
| WO-2009151589-A1 | DIAZACARBAZOLES AND METHODS OF USE | GENENTECH, INC. (US) | 2009-12-17 | — | — | WO | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (2 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20110124654-A1 | DIAZACARBAZOLES AND METHODS OF USE | CHEK1, CHEK2, BUB1B | TOP1 60/4885KDM4E 1507/4885SMN1; SMN2 2926/4885 |
| US-20150368244-A1 | DIAZACARBAZOLES AND METHODS OF USE | CHEK1, CHEK2, BUB1B | TOP1 60/4885KDM4E 1507/4885SMN1; SMN2 2926/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.