Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | NAMPT | P43490 | 1/20 | 0.46 |
| ▸ | HSD11B1 | P28845 | 1/20 | 0.46 |
| ▸ | AURKA | O14965 | 1/20 | 0.46 |
| ▸ | PTPN1 | P18031 | 4/20 | 0.45 |
| ▸ | PTPN2 | P17706 | 2/20 | 0.45 |
| ▸ | RIPK2 | O43353 | 1/20 | 0.44 |
| ▸ | EGFR | P00533 | 1/20 | 0.44 |
| ▸ | KDR | P35968 | 1/20 | 0.44 |
| ▸ | TGFBR1 | P36897 | 1/20 | 0.44 |
| ▸ | MCL1 | Q07820 | 5/20 | 0.43 |
| ▸ | WNT3A | P56704 | 1/20 | 0.42 |
| ▸ | PIK3CD | O00329 | 1/20 | 0.42 |
| ▸ | PTPN6 | P29350 | 1/20 | 0.41 |
| ▸ | PTPN11 | Q06124 | 1/20 | 0.41 |
| ▸ | KEAP1 | Q14145 | 1/20 | 0.41 |
| ▸ | NFE2L2 | Q16236 | 1/20 | 0.41 |
| ▸ | NPC1 | O15118 | 1/20 | 0.41 |
| ▸ | RAB9A | P51151 | 1/20 | 0.41 |
| ▸ | FFAR1 | O14842 | 1/20 | 0.41 |
| ▸ | HIF1A | Q16665 | 1/20 | 0.41 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL1846865 | 0.85 | RIPK2 (0.54) | NAMPTHSD11B1AURKARIPK2EGFR | |
| SCHEMBL3311143 | 0.83 | DYRK2 (0.45) | NAMPTHSD11B1AURKAPTPN1RIPK2 | |
| SCHEMBL22341666 | 0.82 | HSD11B1 (0.63) | NAMPTHSD11B1AURKARIPK2EGFR | |
| SCHEMBL3301474 | 0.81 | RIPK2 (0.43) | HSD11B1AURKARIPK2EGFRKDR | |
| SCHEMBL1849737 | 0.79 | AURKA (0.56) | NAMPTHSD11B1AURKARIPK2EGFR | |
| SCHEMBL1851318 | 0.76 | TRPV3 (0.44) | RIPK2EGFRKDRTGFBR1PIK3CD | |
| SCHEMBL13539289 | 0.74 | NPC1 (0.48) | RIPK2KDRTGFBR1PIK3CDNPC1 | |
| SCHEMBL13394460 | 0.74 | DYRK1A (0.42) | RIPK2EGFRKDRTGFBR1PIK3CD | |
| SCHEMBL22341606 | 0.73 | NPC1 (0.58) | NAMPTHSD11B1NPC1RAB9A | |
| SCHEMBL4870704 | 0.73 | PTPN1 (0.67) | PTPN1PTPN2WNT3APTPN6PTPN11 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-2323697-A2 | IMAGING AGENTS USEFUL FOR IDENTIFYING AD PATHOLOGY | Siemens Medical Solutions USA, Inc. (US) | 2011-05-25 | — | — | EP | disclosed |
| WO-2010011964-A2 | IMAGING AGENTS USEFUL FOR IDENTIFYING AD PATHOLOGY | SIEMENS MEDICAL SOLUTIONS USA, INC. (US) | 2010-01-28 | — | — | WO | disclosed |