Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | F11 | P03951 | 2/20 | 0.41 |
| ▸ | CNR2 | P34972 | 7/20 | 0.37 |
| ▸ | DHODH | Q02127 | 2/20 | 0.37 |
| ▸ | KMT2A | Q03164 | 3/20 | 0.36 |
| ▸ | NPC1 | O15118 | 1/20 | 0.36 |
| ▸ | RAB9A | P51151 | 1/20 | 0.36 |
| ▸ | MEN1 | O00255 | 2/20 | 0.36 |
| ▸ | USP2 | O75604 | 1/20 | 0.36 |
| ▸ | PABPC1 | P11940 | 1/20 | 0.36 |
| ▸ | CYP2D6 | P10635 | 2/20 | 0.35 |
| ▸ | CYP2C9 | P11712 | 2/20 | 0.35 |
| ▸ | CYP2C19 | P33261 | 2/20 | 0.35 |
| ▸ | CYP1A2 | P05177 | 1/20 | 0.35 |
| ▸ | CYP3A4 | P08684 | 1/20 | 0.35 |
| ▸ | POLB | P06746 | 1/20 | 0.35 |
| ▸ | PAICS | P22234 | 1/20 | 0.34 |
| ▸ | ADAM17 | P78536 | 1/20 | 0.34 |
| ▸ | MRGPRX1 | Q96LB2 | 1/20 | 0.33 |
| ▸ | IDO1 | P14902 | 1/20 | 0.33 |
| ▸ | F10 | P00742 | 1/20 | 0.33 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL185393 | 0.85 | CNR2 (0.42) | CNR2RAB9ACYP2D6CYP2C19CYP1A2 | |
| SCHEMBL2808559 | 0.84 | F11 (0.39) | F11CNR2DHODHKMT2ANPC1 | |
| Trifluoroacetic Acid SCHEMBL14856625 | 0.83 | CNR2 (0.40) | CNR2RAB9ACYP2D6CYP2C19CYP1A2 | |
| SCHEMBL185746 | 0.79 | F11 (0.40) | F11DHODHKMT2AMEN1USP2 | |
| SCHEMBL185476 | 0.77 | KIT (0.40) | CNR2DHODH | |
| SCHEMBL2807962 | 0.77 | F11 (0.35) | F11CNR2KMT2ANPC1RAB9A | |
| SCHEMBL185808 | 0.76 | FLT3 (0.39) | CNR2DHODHNPC1RAB9ACYP2D6 | |
| SCHEMBL185747 | 0.74 | CNR2 (0.39) | CNR2RAB9ACYP2D6CYP2C19CYP1A2 | |
| Trifluoroacetic Acid SCHEMBL14856648 | 0.74 | FLT3 (0.38) | CNR2DHODHNPC1RAB9A | |
| SCHEMBL185884 | 0.73 | CNR2 (0.38) | CNR2NPC1RAB9ACYP2D6CYP2C19 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 3 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-2401256-B1 | Compounds as bradykinin B1 antagonists | BOEHRINGER INGELHEIM INT (DE) | 2013-04-17 | — | — | EP | disclosed |
| EP-2401256-A1 | COMPOUNDS AS BRADYKININ B1 ANTAGONISTS | Boehringer Ingelheim International GmbH (DE) | 2012-01-04 | — | — | EP | disclosed |
| WO-2010097372-A1 | COMPOUNDS AS BRADYKININ B1 ANTAGONISTS | BOEHRINGER INGELHEIM INTERNATIONAL GMBH (DE) | 2010-09-02 | — | — | WO | disclosed |