Predicted protein targets (top 16)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | GPR52 | Q9Y2T5 | 8/20 | 0.63 |
| ▸ | SMN1; SMN2 | Q16637 | 2/20 | 0.43 |
| ▸ | MAPT | P10636 | 2/20 | 0.41 |
| ▸ | MEN1 | O00255 | 1/20 | 0.41 |
| ▸ | LMNA | P02545 | 1/20 | 0.41 |
| ▸ | HTT | P42858 | 1/20 | 0.41 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.41 |
| ▸ | NPSR1 | Q6W5P4 | 1/20 | 0.41 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.41 |
| ▸ | HPGD | P15428 | 1/20 | 0.41 |
| ▸ | SNCA | P37840 | 1/20 | 0.41 |
| ▸ | L3MBTL1 | Q9Y468 | 1/20 | 0.39 |
| ▸ | TP53 | P04637 | 1/20 | 0.39 |
| ▸ | TRPV1 | Q8NER1 | 1/20 | 0.38 |
| ▸ | NPC1 | O15118 | 1/20 | 0.38 |
| ▸ | RAB9A | P51151 | 1/20 | 0.38 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL1846595 | 0.90 | GPR52 (0.65) | GPR52MAPTKMT2AALDH1A1HPGD | |
| SCHEMBL3219252 | 0.88 | GPR52 (0.77) | GPR52SMN1; SMN2MEN1KMT2ASNCA | |
| SCHEMBL1849559 | 0.85 | GPR52 (0.52) | GPR52SMN1; SMN2MAPTMEN1LMNA | |
| SCHEMBL3208741 | 0.85 | GPR52 (0.62) | GPR52MAPTSNCAL3MBTL1NPC1 | |
| SCHEMBL1852323 | 0.82 | GPR52 (0.49) | GPR52SMN1; SMN2MAPTMEN1LMNA | |
| SCHEMBL1855788 | 0.82 | GPR52 (0.58) | GPR52MAPTSNCA | |
| SCHEMBL3212711 | 0.81 | GPR52 (0.55) | GPR52L3MBTL1NPC1RAB9A | |
| SCHEMBL3222089 | 0.78 | GPR52 (0.78) | GPR52MAPTSNCA | |
| SCHEMBL1852679 | 0.78 | GPR52 (0.72) | GPR52HTTHPGD | |
| SCHEMBL1851771 | 0.78 | GPR52 (1.00) | GPR52 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-2323978-A1 | AMIDE COMPOUND | Takeda Pharmaceutical Company Limited (JP) | 2011-05-25 | — | — | EP | disclosed |
| WO-2010018874-A1 | AMIDE COMPOUND | TAKEDA PHARMACEUTICAL COMPANY LIMITED (JP) | 2010-02-18 | — | — | WO | disclosed |