SCHEMBL3222089

SCHEMBL3222089

O=C(NCCO)c1cccc(-c2cccc3cc(Cc4cccc(F)c4)oc23)c1

nearest known ligand 0.78

Predicted protein targets (top 4)

geneUniProtsupporting neighboursconfidence
GPR52 Q9Y2T5 14/20 0.78
GAA P10253 1/20 0.44
SNCA P37840 3/20 0.43
MAPT P10636 1/20 0.41

Click a target to see other patent compounds predicted against it — the reverse direction, in place.

Similar compounds — the chemically nearest patent molecules

Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.

Compoundsimilaritytop predictedshared targets
SCHEMBL1849493 0.90 GPR52 (0.75) GPR52
SCHEMBL3219252 0.89 GPR52 (0.77) GPR52GAASNCA
SCHEMBL1846595 0.88 GPR52 (0.65) GPR52GAASNCAMAPT
SCHEMBL1852679 0.88 GPR52 (0.72) GPR52
SCHEMBL1851771 0.88 GPR52 (1.00) GPR52
SCHEMBL1854347 0.85 GPR52 (0.56) GPR52
SCHEMBL1846596 0.80 GPR52 (0.53) GPR52
SCHEMBL3210616 0.80 GPR52 (0.61) GPR52MAPT
SCHEMBL3208741 0.79 GPR52 (0.62) GPR52SNCAMAPT
SCHEMBL1849554 0.78 GPR52 (0.63) GPR52SNCAMAPT

Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.

Patent provenance — the patents this molecule appears in, and who filed them

Claimed or disclosed in 4 patents. claimed = in the patent's claims; disclosed = body only.

PatentTitleAssigneePublishedPriorityFilingCountryStatus
WO-2010018874-A1 AMIDE COMPOUND TAKEDA PHARMACEUTICAL COMPANY LIMITED (JP) 2010-02-18 WO disclosed
US-20100041891-A1 AMIDE COMPOUND TAKEDA PHARMACEUTICAL COMPANY LIMITED (JP) 2010-02-18 US disclosed
US-20100041891-A1 AMIDE COMPOUND TAKEDA PHARMACEUTICAL COMPANY LIMITED (JP) 2010-02-18 US disclosed
US-20100041891-A1 AMIDE COMPOUND TAKEDA PHARMACEUTICAL COMPANY LIMITED (JP) 2010-02-18 US disclosed

Patent text — is the patent's own abstract consistent with the prediction?

For each of this compound's patents that has machine-readable text (1 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.

PatentTitleText reads most aboutPredicted target · text-rank
US-20100041891-A1 AMIDE COMPOUND GPR52, GPR132, NR5A2 GPR52 1/4885GAA 4210/4885SNCA 2055/4885

“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.