Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | LMNA | P02545 | 2/20 | 0.45 |
| ▸ | ALDH1A1 | P00352 | 2/20 | 0.42 |
| ▸ | HPGD | P15428 | 3/20 | 0.41 |
| ▸ | HTT | P42858 | 1/20 | 0.41 |
| ▸ | F2 | P00734 | 1/20 | 0.40 |
| ▸ | PRSS1 | P07477 | 1/20 | 0.40 |
| ▸ | ROCK2 | O75116 | 2/20 | 0.39 |
| ▸ | HRH3 | Q9Y5N1 | 1/20 | 0.39 |
| ▸ | PKM | P14618 | 2/20 | 0.38 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.38 |
| ▸ | TUBB4A | P04350 | 1/20 | 0.38 |
| ▸ | TUBB | P07437 | 1/20 | 0.38 |
| ▸ | TUBA3C | P0DPH7 | 1/20 | 0.38 |
| ▸ | TUBA1B | P68363 | 1/20 | 0.38 |
| ▸ | TUBA4A | P68366 | 1/20 | 0.38 |
| ▸ | TUBB4B | P68371 | 1/20 | 0.38 |
| ▸ | TUBB3 | Q13509 | 1/20 | 0.38 |
| ▸ | TUBB2A | Q13885 | 1/20 | 0.38 |
| ▸ | TUBB8 | Q3ZCM7 | 1/20 | 0.38 |
| ▸ | TUBA3E | Q6PEY2 | 1/20 | 0.38 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL3608832 | 0.77 | ROCK1 (0.52) | ROCK2ROCK1 | |
| SCHEMBL3601935 | 0.77 | TNIK (0.42) | ROCK2ROCK1 | |
| SCHEMBL3595639 | 0.77 | CDK9 (0.46) | ALDH1A1ROCK2ROCK1 | |
| SCHEMBL1849606 | 0.72 | ACACB (0.38) | LMNAALDH1A1HPGDHTTSMN1; SMN2 | |
| SCHEMBL26995259 | 0.67 | ACACB (0.44) | LMNAHPGDHTT | |
| SCHEMBL26985869 | 0.67 | ACACB (0.44) | LMNAHPGDHTT | |
| SCHEMBL611142 | 0.67 | ACACB (0.44) | LMNAHPGDHTTPKMSMN1; SMN2 | |
| SCHEMBL612470 | 0.67 | KCNH2 (0.43) | LMNAHPGDHTT | |
| SCHEMBL10235919 | 0.65 | CNR1 (0.43) | LMNAALDH1A1HPGDSMN1; SMN2 | |
| SCHEMBL7986405 | 0.65 | KDM4E (0.55) | LMNAHTTF2PRSS1HRH3 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-2323659-A1 | COMPOUNDS USEFUL AS INHIBITORS OF PROTEIN KINASES | Abbott Laboratories (US) | 2011-05-25 | — | — | EP | disclosed |