Predicted protein targets (top 2)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | IRAK4 | Q9NWZ3 | 19/20 | 0.45 |
| ▸ | IDO1 | P14902 | 1/20 | 0.40 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL18497827 | 0.90 | IRAK4 (0.45) | IRAK4IDO1 | |
| SCHEMBL18497751 | 0.82 | IDO1 (0.56) | IDO1 | |
| SCHEMBL18497837 | 0.81 | CHEK2 (0.48) | IRAK4IDO1 | |
| SCHEMBL18497836 | 0.81 | CHEK2 (0.48) | IRAK4IDO1 | |
| SCHEMBL17148571 | 0.73 | IRAK4 (0.61) | IRAK4 | |
| SCHEMBL28895363 | 0.73 | PDGFRA (0.56) | — | |
| SCHEMBL18497817 | 0.72 | CHEK2 (0.47) | IRAK4IDO1 | |
| SCHEMBL18497816 | 0.72 | CHEK2 (0.47) | IRAK4IDO1 | |
| SCHEMBL16828711 | 0.72 | CNR2 (0.38) | — | |
| SCHEMBL18525646 | 0.71 | IRAK4 (0.62) | IRAK4 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| WO-2017025849-A1 | BICYCLIC-FUSED HETEROARYL OR ARYL COMPOUNDS | PFIZER INC. (US) | 2017-02-16 | — | — | WO | disclosed |