Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | MAPT | P10636 | 2/20 | 0.58 |
| ▸ | GAA | P10253 | 1/20 | 0.48 |
| ▸ | MAPK1 | P28482 | 1/20 | 0.48 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.44 |
| ▸ | MEN1 | O00255 | 1/20 | 0.44 |
| ▸ | ALOX15B | O15296 | 1/20 | 0.44 |
| ▸ | NR1I2 | O75469 | 1/20 | 0.44 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.44 |
| ▸ | LMNA | P02545 | 1/20 | 0.44 |
| ▸ | TP53 | P04637 | 1/20 | 0.44 |
| ▸ | HSP90AA1 | P07900 | 1/20 | 0.44 |
| ▸ | CYP3A4 | P08684 | 1/20 | 0.44 |
| ▸ | HTR1A | P08908 | 1/20 | 0.44 |
| ▸ | ALOX5 | P09917 | 1/20 | 0.44 |
| ▸ | MMP9 | P14780 | 1/20 | 0.44 |
| ▸ | ALOX15 | P16050 | 1/20 | 0.44 |
| ▸ | ALOX12 | P18054 | 1/20 | 0.44 |
| ▸ | SLC6A2 | P23975 | 1/20 | 0.44 |
| ▸ | OPRK1 | P41145 | 1/20 | 0.44 |
| ▸ | HTT | P42858 | 1/20 | 0.44 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL14130456 | 1.00 | MAPT (0.58) | MAPTGAAMAPK1KDM4EMEN1 | |
| SCHEMBL10027182 | 0.86 | GAA (0.60) | MAPTGAAMAPK1KDM4EMEN1 | |
| SCHEMBL10027181 | 0.84 | MAPT (0.54) | MAPTGAAMAPK1KDM4EMEN1 | |
| SCHEMBL14372990 | 0.80 | MAPT (0.58) | MAPTKDM4EMEN1ALOX15BNR1I2 | |
| SCHEMBL3819661 | 0.80 | MAPT (0.58) | MAPTGAAMAPK1KDM4EMEN1 | |
| SCHEMBL16106990 | 0.75 | MAPT (0.53) | MAPTKDM4EMEN1ALOX15BNR1I2 | |
| Chlorquinaldol SCHEMBL301405 | 0.74 | MAPT (1.00) | MAPTGAAKDM4EMEN1ALOX15B | |
| Chlorquinaldol SCHEMBL29641617 | 0.74 | MAPT (1.00) | MAPTGAAKDM4EMEN1ALOX15B | |
| Chlorquinaldol SCHEMBL29607534 | 0.74 | MAPT (1.00) | MAPTGAAKDM4EMEN1ALOX15B | |
| Chlorquinaldol SCHEMBL11746430 | 0.74 | MAPT (1.00) | MAPTGAAKDM4EMEN1ALOX15B |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 5 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-11434203-B2 | 8-hydroxyquinoline derivatives as diagnostic and therapeutic agents | THE GENERAL HOSPITAL CORPORATION (US) | 2022-09-06 | — | — | US | disclosed |
| US-20210024468-A1 | 8-HYDROXYQUINOLINE DERIVATIVES AS DIAGNOSTIC AND THERAPEUTIC AGENTS | THE GENERAL HOSPITAL CORPORATION | 2021-01-28 | — | — | US | disclosed |
| US-10781178-B2 | 8-hydroxyquinoline derivatives as diagnostic and therapeutic agents | THE GENERAL HOSPITAL CORPORATION (US) | 2020-09-22 | — | — | US | disclosed |
| US-20180327362-A1 | 8-HYDROXYQUINOLINE DERIVATIVES AS DIAGNOSTIC AND THERAPEUTIC AGENTS | THE GENERAL HOSPITAL CORPORATION | 2018-11-15 | — | — | US | disclosed |
| WO-2017027064-A1 | 8-HYDROXYQUINOLINE DERIVATIVES AS DIAGNOSTIC AND THERAPEUTIC AGENTS | THE GENERAL HOSPITAL CORPORATION (US) | 2017-02-16 | — | — | WO | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (4 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-11434203-B2 | 8-hydroxyquinoline derivatives as diagnostic and therapeutic agents | KLK3, COQ8A, PARK7 | MAPT 33/4885GAA 439/4885MAPK1 3168/4885 |
| US-20210024468-A1 | 8-HYDROXYQUINOLINE DERIVATIVES AS DIAGNOSTIC AND THERAPEUTIC AGENTS | KLK3, COQ8A, PARK7 | MAPT 33/4885GAA 439/4885MAPK1 3168/4885 |
| US-20180327362-A1 | 8-HYDROXYQUINOLINE DERIVATIVES AS DIAGNOSTIC AND THERAPEUTIC AGENTS | KLK3, COQ8A, PARK7 | MAPT 33/4885GAA 439/4885MAPK1 3168/4885 |
| US-10781178-B2 | 8-hydroxyquinoline derivatives as diagnostic and therapeutic agents | KLK3, COQ8A, PARK7 | MAPT 33/4885GAA 439/4885MAPK1 3168/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.