Sugi Predict

Sugi Predict / Targets / COQ8A

COQ8A

Atypical kinase COQ8A, mitochondrial · Q8NI60 · COQ8A on Sugi Atlas →

5,280 patent compounds predicted against COQ8A, 4,029 high-confidence (nearest known ligand ≥ 0.5)

Top predicted compounds (top 20 by supporting neighbours, then confidence)

CompoundConfidenceSupporting neighbours
SCHEMBL858213 SCHEMBL858213 0.64 11/20
SCHEMBL2292717 SCHEMBL2292717 0.60 10/20
SCHEMBL2289246 SCHEMBL2289246 0.65 9/20
Hydrochloric Acid Hydrochloric Acid (SCHEMBL2291538) 0.64 9/20
SCHEMBL2589417 SCHEMBL2589417 0.54 9/20
SCHEMBL2596047 SCHEMBL2596047 0.52 9/20
SCHEMBL2588265 SCHEMBL2588265 0.51 9/20
SCHEMBL2594633 SCHEMBL2594633 0.50 9/20
SCHEMBL2595311 SCHEMBL2595311 0.52 8/20
SCHEMBL2594637 SCHEMBL2594637 0.48 8/20
SCHEMBL2594532 SCHEMBL2594532 0.46 8/20
SCHEMBL2592801 SCHEMBL2592801 0.55 7/20
SCHEMBL2446373 SCHEMBL2446373 0.55 6/20
SCHEMBL2594398 SCHEMBL2594398 0.53 6/20
SCHEMBL2596136 SCHEMBL2596136 0.52 6/20
SCHEMBL857882 SCHEMBL857882 0.50 6/20
SCHEMBL724133 SCHEMBL724133 0.53 5/20
SCHEMBL725132 SCHEMBL725132 0.41 5/20
SCHEMBL1172280 SCHEMBL1172280 0.66 4/20
SCHEMBL2205672 SCHEMBL2205672 0.65 4/20

Clinical trials — most relevant to COQ8A by text similarity (a relevance ranking, not an exhaustive list)

TrialPhaseStatus
Phase III Trial of Coenzyme Q10 in Mitochondrial Disease PHASE3COMPLETED
Clinical Evaluation of the Effect of Metformin in Sepsis PHASE3UNKNOWN
A Study of the Efficacy and Safety of MT1621 in Thymidine Kinase 2 (TK2) Deficiency (Treatment naïve) PHASE3WITHDRAWN
A Study of Efficacy, Safety and Tolerability of Idebenone in the Treatment of Friedreich's Ataxia (FRDA) Patients PHASE3COMPLETED
Mitochondrial Dysfunction in the Pathophysiology and Treatment of Bipolar Disorder PHASE2WITHDRAWN
Prevent Cardiac Surgery Associated AKI Trial PHASE2RECRUITING
A Study of Bezafibrate in Mitochondrial Myopathy PHASE2COMPLETED
Nicotinamide Riboside on Mitochondrial Function in Li-Fraumeni Syndrome PHASE1/PHASE2COMPLETED
Trial of Nicotinamide Riboside and Co-enzyme Q10 in Chronic Kidney Disease PHASE2COMPLETED
Effects of Coenzyme Q10 on Charcot-Marie-Tooth Disease PHASE1/PHASE2COMPLETED
Parkinson's Disease Treatment With Coenzyme Q10 PHASE2COMPLETED
Does Clinical Treatment of Mitochondrial Dysfunction Impact Autism Spectrum Disorder (ASD)? PHASE1UNKNOWN
Tissue Sample Study for Mitochondrial Disorders nanENROLLING_BY_INVITATION
Independent and Additive Effects Of Micronutrients With Metformin In Patients With PCOS nanCOMPLETED
Evaluation of Ubiquinol on Mitochondrial Oxidative Capacity in Statin Patients Using 31PMRS nanCOMPLETED
Genomic Profiling of Mitochondrial Disease - Imaging Analysis for Precise Mitochondrial Medicine nanCOMPLETED
Exercise Training Effects on Muscle Function in Adults With Mitochondrial Myopathy nanRECRUITING
The Natural History of Mitochondrial Diseases nanRECRUITING
MITOMICS : a Multi-OMICS Approach for the Diagnosis of Mitochondrial Diseases nanRECRUITING
The Genetics of Diabetes in Southern California Chinese Americans nanWITHDRAWN
Pharmacokinetic Study on Three Formulations of Coenzyme Q10 With Different Carriers nanUNKNOWN
Clinical Study of Hydroxytyrosol (HT) in Mitochondrial Diseases nanCOMPLETED
Gastrointestinal Dysfunction in Children Affected With Mitochondrial Disorders nanCOMPLETED
Effect of Diaphragm Stimulation During Surgery nanCOMPLETED
North American Mitochondrial Disease Consortium Patient Registry and Biorepository (NAMDC) nanRECRUITING
Nicotinamide Riboside and Mitochondrial Biogenesis nanCOMPLETED
Effect of Subtle Energy Transmission and Tao Calligraphy Mindfulness Practice on Mitochondrial DNA in Peripheral Blood Leukocytes nanNOT_YET_RECRUITING
Combined Effects of Statins and Exercise on Training Sensitive Health Markers nanCOMPLETED
Mitochondrial Dysfunction in Phelan-McDermid Syndrome nanCOMPLETED
Cross-linked Hyaluronic Acid and Coenzyme Q10 in the Treatment of Dry Eye nanCOMPLETED

Related proteins — ESM-2 sequence neighbours (a COQ8A binder may also engage these)

ProteinNameSimilarity
Q5BJQ0 — 1.000 Q5BJQ0 →
Q60936 — 1.000 Q60936 →
Q5RGU1 — 1.000 Q5RGU1 →
A3QJU3 — 0.999 A3QJU3 →
Q29RI0 — 0.997 Q29RI0 →
Q6AY19 — 0.993 Q6AY19 →
Q9SBB2 — 0.991 Q9SBB2 →
Q18486 — 0.989 Q18486 →
Q92338 — 0.989 Q92338 →
A6QLI6 — 0.986 A6QLI6 →
Q9XS79 — 0.985 Q9XS79 →
Q9UQ90 — 0.984 Q9UQ90 →
Q63147 — 0.984 Q63147 →
Q5R9R9 — 0.984 Q5R9R9 →
Q9CQN1 — 0.984 Q9CQN1 →
P07997 — 0.984 P07997 →
Q7TT47 — 0.984 Q7TT47 →
Q566J8 — 0.983 Q566J8 →
Q8MKN0 — 0.983 Q8MKN0 →
P13196 — 0.983 P13196 →
Q9H4I3 — 0.983 Q9H4I3 →
P34649 — 0.983 P34649 →
P27472 — 0.983 P27472 →
Q3ZC31 — 0.983 Q3ZC31 →
Q38970 — 0.983 Q38970 →
Q8MJ26 — 0.983 Q8MJ26 →
A2YQ56 — 0.982 A2YQ56 →
TRAP1 Heat shock protein 75 kDa, mitochondrial 0.982 landscape →
A9NNH7 — 0.982 A9NNH7 →
P22557 — 0.982 P22557 →