Predicted protein targets (top 17)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | GPR52 | Q9Y2T5 | 3/20 | 0.44 |
| ▸ | ALDH1A1 | P00352 | 3/20 | 0.36 |
| ▸ | HTT | P42858 | 1/20 | 0.36 |
| ▸ | RAB9A | P51151 | 1/20 | 0.36 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.36 |
| ▸ | MLYCD | O95822 | 1/20 | 0.35 |
| ▸ | HPGD | P15428 | 2/20 | 0.32 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.32 |
| ▸ | MAPT | P10636 | 1/20 | 0.32 |
| ▸ | HSD17B10 | Q99714 | 1/20 | 0.32 |
| ▸ | MAPKAPK2 | P49137 | 1/20 | 0.31 |
| ▸ | PARP1 | P09874 | 1/20 | 0.31 |
| ▸ | EIF4EBP1 | Q13541 | 1/20 | 0.30 |
| ▸ | HDAC1 | Q13547 | 1/20 | 0.30 |
| ▸ | HDAC8 | Q9BY41 | 1/20 | 0.30 |
| ▸ | HDAC6 | Q9UBN7 | 1/20 | 0.30 |
| ▸ | PDK1 | Q15118 | 1/20 | 0.30 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL1850388 | 0.93 | GPR52 (0.43) | GPR52ALDH1A1HTTRAB9ASMN1; SMN2 | |
| SCHEMBL1855790 | 0.89 | GPR52 (0.45) | GPR52ALDH1A1HTTRAB9ASMN1; SMN2 | |
| SCHEMBL1846596 | 0.82 | GPR52 (0.53) | GPR52ALDH1A1HPGDPDK1 | |
| SCHEMBL3210616 | 0.82 | GPR52 (0.61) | GPR52MAPT | |
| SCHEMBL1849555 | 0.80 | GPR52 (0.51) | GPR52ALDH1A1RAB9AHPGDMAPT | |
| SCHEMBL1855057 | 0.80 | GPR52 (0.54) | GPR52EIF4EBP1HDAC6 | |
| SCHEMBL1849844 | 0.79 | GPR52 (0.57) | GPR52EIF4EBP1 | |
| SCHEMBL1856476 | 0.75 | GPR52 (0.51) | GPR52ALDH1A1RAB9ASMN1; SMN2HPGD | |
| SCHEMBL3218910 | 0.75 | GPR52 (0.58) | GPR52MAPTEIF4EBP1 | |
| SCHEMBL1849493 | 0.74 | GPR52 (0.75) | GPR52 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-2323978-A1 | AMIDE COMPOUND | Takeda Pharmaceutical Company Limited (JP) | 2011-05-25 | — | — | EP | disclosed |
| WO-2010018874-A1 | AMIDE COMPOUND | TAKEDA PHARMACEUTICAL COMPANY LIMITED (JP) | 2010-02-18 | — | — | WO | disclosed |