SCHEMBL18498665

SCHEMBL18498665

CCS(=O)(=O)c1ccc(N)nc1-c1nc2cc(C(F)(F)F)cnc2n1C

nearest known ligand 0.44

Predicted protein targets (top 9)

geneUniProtsupporting neighboursconfidence
▸ POLB P06746 2/20 0.44
▸ DDR1 Q08345 10/20 0.34
▸ ALOX5AP P20292 1/20 0.34
▸ FEN1 P39748 1/20 0.34
▸ SLC40A1 Q9NP59 1/20 0.33
▸ KCNH2 Q12809 1/20 0.32
▸ S1PR1 P21453 1/20 0.32
▸ BACE1 P56817 1/20 0.32
▸ LRRK2 Q5S007 1/20 0.32

Click a target to see other patent compounds predicted against it — the reverse direction, in place.

Similar compounds — the chemically nearest patent molecules

Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.

Compoundsimilaritytop predictedshared targets
SCHEMBL17844037 0.90 POLB (0.44) POLBDDR1
SCHEMBL23507301 0.90 POLB (0.45) POLBDDR1S1PR1LRRK2
SCHEMBL18498763 0.89 POLB (0.45) POLBDDR1S1PR1LRRK2
SCHEMBL30002340 0.88 POLB (0.43) POLBDDR1S1PR1LRRK2
SCHEMBL31608704 0.86 POLB (0.43) POLBDDR1S1PR1LRRK2
SCHEMBL21051264 0.86 POLB (0.43) POLBDDR1S1PR1LRRK2
SCHEMBL21051267 0.86 POLB (0.43) POLBDDR1S1PR1LRRK2
SCHEMBL14684583 0.85 POLB (0.48) POLBDDR1ALOX5APFEN1S1PR1
SCHEMBL29360277 0.85 POLB (0.48) POLBDDR1ALOX5APFEN1S1PR1
SCHEMBL16376050 0.84 POLB (0.45) POLBDDR1ALOX5APFEN1KCNH2

Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.

Patent provenance — the patents this molecule appears in, and who filed them

Claimed or disclosed in 21 patents — showing the first 20. claimed = in the patent's claims; disclosed = body only.

PatentTitleAssigneePublishedPriorityFilingCountryStatus
US-20250361231-A1 FUSED RING COMPOUNDS WITH SULFUR-CONTAINING SUBSTITUENTS, PREPARATION METHODS, INSECTICIDE COMPOSITIONS, AND APPLICATION JIANGSU FLAG CHEMICAL INDUSTRY CO., LTD (CN) 2025-11-27 — — US disclosed
EP-4563581-A1 FUSED RING COMPOUND WITH SULFUR-CONTAINING SUBSTITUENT, PREPARATION METHOD, INSECTICIDE COMPOSITION, AND USE Jiangsu Flag Chemical Industry Co., Ltd (CN) 2025-06-04 — — EP disclosed
CN-115181116-B Fused ring compound with sulfur-containing substituent, preparation method, pesticide composition and application 江苏中旗科技股份有限公司 2024-11-26 — — CN disclosed
CN-118955472-A 2- (Hetero) aryl substituted fused heterocyclic derivatives as pesticides 拜耳作物科学股份公司 2024-11-15 — — CN disclosed
CN-115181116-A Fused ring compound with sulfur-containing substituent, preparation method, pesticide composition and application 江苏中旗科技股份有限公司 2022-10-14 — — CN disclosed
EP-3896066-A2 2-(HET)ARYL-SUBSTITUTED CONDENSED HETEROCYCLE DERIVATIVES AS PESTICIDES Bayer CropScience Aktiengesellschaft (DE) 2021-10-20 — — EP disclosed
EP-3896066-A2 2-(HET)ARYL-SUBSTITUTED CONDENSED HETEROCYCLE DERIVATIVES AS PESTICIDES Bayer CropScience Aktiengesellschaft (DE) 2021-10-20 — — EP disclosed
EP-3896065-A1 2-(HET)ARYL-SUBSTITUTED CONDENSED HETEROCYCLE DERIVATIVES AS PESTICIDES Bayer CropScience Aktiengesellschaft (DE) 2021-10-20 — — EP disclosed
EP-3896065-A1 2-(HET)ARYL-SUBSTITUTED CONDENSED HETEROCYCLE DERIVATIVES AS PESTICIDES Bayer CropScience Aktiengesellschaft (DE) 2021-10-20 — — EP disclosed
EP-3331870-B1 2-(HET)ARYL-SUBSTITUTED CONDENSED HETEROCYCLE DERIVATIVES AS PESTICIDES BAYER CROPSCIENCE AG (DE) 2021-06-16 — — EP disclosed
US-10986840-B2 2-(het)aryl-substituted fused heterocycle derivatives as pesticides BAYER CROPSCIENCE AKTIENGESELLSCHAFT (DE) 2021-04-27 — — US disclosed
US-10986840-B2 2-(het)aryl-substituted fused heterocycle derivatives as pesticides BAYER CROPSCIENCE AKTIENGESELLSCHAFT (DE) 2021-04-27 — — US disclosed
US-10667517-B2 2-(Het)aryl-substituted fused heterocycle derivatives as pesticides BAYER CROPSCIENCE AKTIENGESELLSCHAFT (DE) 2020-06-02 — — US disclosed
US-10667517-B2 2-(Het)aryl-substituted fused heterocycle derivatives as pesticides BAYER CROPSCIENCE AKTIENGESELLSCHAFT (DE) 2020-06-02 — — US disclosed
US-20200029567-A1 2-(Het)aryl-substituted fused heterocycle derivatives as pesticides BAYER CROPSCIENCE AKTIENGESELLSCHAFT (DE) 2020-01-30 — — US disclosed
US-20200029567-A1 2-(Het)aryl-substituted fused heterocycle derivatives as pesticides BAYER CROPSCIENCE AKTIENGESELLSCHAFT (DE) 2020-01-30 — — US disclosed
US-20180271099-A1 2-(Het)aryl-substituted fused heterocycle derivatives as pesticides BAYER CROPSCIENCE AKTIENGESELLSCHAFT (DE) 2018-09-27 — — US disclosed
EP-3331870-A2 2-(HET)ARYL-SUBSTITUTED CONDENSED HETEROCYCLIC DERIVATIVES AS PEST CONTROL AGENTS Bayer CropScience Aktiengesellschaft (DE) 2018-06-13 — — EP disclosed
WO-2017025419-A2 2-(HET)ARYL-SUBSTITUTED CONDENSED HETEROCYCLIC DERIVATIVES AS PEST CONTROL AGENTS BAYER CROPSCIENCE AKTIENGESELLSCHAFT (DE) 2017-02-16 — — WO disclosed
WO-2017025419-A2 2-(HET)ARYL-SUBSTITUTED CONDENSED HETEROCYCLIC DERIVATIVES AS PEST CONTROL AGENTS BAYER CROPSCIENCE AKTIENGESELLSCHAFT (DE) 2017-02-16 — — WO disclosed

Patent text — is the patent's own abstract consistent with the prediction?

For each of this compound's patents that has machine-readable text (5 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.

PatentTitleText reads most aboutPredicted target · text-rank
US-20250361231-A1 FUSED RING COMPOUNDS WITH SULFUR-CONTAINING SUBSTITUENTS, PREPARATION METHODS, INSECTICIDE COMPOSITIONS, AND APPLICATION DDT, CBS, GSS POLB 4622/4885DDR1 2557/4885ALOX5AP 3225/4885
US-10667517-B2 2-(Het)aryl-substituted fused heterocycle derivatives as pesticides CYP1A1, CYP8B1, CYP1B1 POLB 4837/4885DDR1 2548/4885ALOX5AP 700/4885
US-20200029567-A1 2-(Het)aryl-substituted fused heterocycle derivatives as pesticides CYP1A1, CYP8B1, CYP1B1 POLB 4837/4885DDR1 2548/4885ALOX5AP 700/4885
US-10986840-B2 2-(het)aryl-substituted fused heterocycle derivatives as pesticides CYP1A1, CYP8B1, CYP1B1 POLB 4837/4885DDR1 2548/4885ALOX5AP 700/4885
US-20180271099-A1 2-(Het)aryl-substituted fused heterocycle derivatives as pesticides CYP1A1, CYP8B1, CYP1B1 POLB 4837/4885DDR1 2548/4885ALOX5AP 700/4885

“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.

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