Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | CCND3 | P30281 | 3/20 | 0.41 |
| ▸ | CDK6 | Q00534 | 3/20 | 0.41 |
| ▸ | CCNK | O75909 | 1/20 | 0.41 |
| ▸ | CDK9 | P50750 | 1/20 | 0.41 |
| ▸ | JAK2 | O60674 | 3/20 | 0.40 |
| ▸ | SYK | P43405 | 5/20 | 0.40 |
| ▸ | CDK4 | P11802 | 3/20 | 0.40 |
| ▸ | CCND1 | P24385 | 3/20 | 0.40 |
| ▸ | CCNA2 | P20248 | 2/20 | 0.40 |
| ▸ | CDK2 | P24941 | 2/20 | 0.40 |
| ▸ | CD63 | P08962 | 1/20 | 0.40 |
| ▸ | TYK2 | P29597 | 2/20 | 0.39 |
| ▸ | LYN | P07948 | 1/20 | 0.38 |
| ▸ | SRC | P12931 | 1/20 | 0.38 |
| ▸ | AHR | P35869 | 1/20 | 0.38 |
| ▸ | BTK | Q06187 | 1/20 | 0.38 |
| ▸ | IKBKE | Q14164 | 2/20 | 0.37 |
| ▸ | TBK1 | Q9UHD2 | 2/20 | 0.37 |
| ▸ | DPP4 | P27487 | 1/20 | 0.37 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.37 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL2474068 | 0.83 | JAK2 (0.47) | JAK2SYKCDK2TYK2BTK | |
| SCHEMBL2474769 | 0.82 | MAP3K11 (0.49) | CDK6SYKCDK2TYK2BTK | |
| SCHEMBL2478695 | 0.82 | SYK (0.42) | CDK6SYKCDK4CCND1LYN | |
| SCHEMBL13288359 | 0.82 | SYK (0.59) | JAK2SYKBTK | |
| SCHEMBL2475810 | 0.80 | SYK (0.44) | CCND3CDK6JAK2SYKCDK4 | |
| SCHEMBL2473718 | 0.80 | SYK (0.45) | JAK2SYKCDK2TYK2LYN | |
| SCHEMBL2476464 | 0.78 | SYK (0.47) | JAK2SYKCDK2TYK2BTK | |
| SCHEMBL18499163 | 0.78 | TYK2 (0.38) | CCND3CDK6JAK2SYKCDK4 | |
| SCHEMBL18499161 | 0.78 | TYK2 (0.38) | CCND3CDK6JAK2SYKCDK4 | |
| SCHEMBL18498988 | 0.76 | SYK (0.40) | CDK6CDK9SYKCDK4CCND1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-9567348-B2 | Substituted pyrazolo[1,5-a]pyrimidines as Syk inhibitors | GILEAD CONNECTICUT, INC. (US) | 2017-02-14 | — | — | US | disclosed |