Predicted protein targets (top 19)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | SYK | P43405 | 3/20 | 0.40 |
| ▸ | CDK2 | P24941 | 12/20 | 0.36 |
| ▸ | CCNE1 | P24864 | 11/20 | 0.36 |
| ▸ | CCNT1 | O60563 | 5/20 | 0.34 |
| ▸ | CDK9 | P50750 | 5/20 | 0.34 |
| ▸ | MAP4K4 | O95819 | 1/20 | 0.33 |
| ▸ | CYP11B1 | P15538 | 1/20 | 0.33 |
| ▸ | CDK1 | P06493 | 3/20 | 0.33 |
| ▸ | CDK4 | P11802 | 3/20 | 0.33 |
| ▸ | CCNA2 | P20248 | 3/20 | 0.33 |
| ▸ | CCND1 | P24385 | 3/20 | 0.33 |
| ▸ | CDK7 | P50613 | 3/20 | 0.33 |
| ▸ | CCNH | P51946 | 3/20 | 0.33 |
| ▸ | CCNA1 | P78396 | 3/20 | 0.33 |
| ▸ | CDK3 | Q00526 | 3/20 | 0.33 |
| ▸ | CDK6 | Q00534 | 2/20 | 0.33 |
| ▸ | CDK5 | Q00535 | 1/20 | 0.33 |
| ▸ | CDK5R1 | Q15078 | 1/20 | 0.33 |
| ▸ | DPP4 | P27487 | 1/20 | 0.31 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL2478607 | 0.83 | SYK (0.59) | SYKCDK2CCNE1 | |
| SCHEMBL18499162 | 0.80 | SYK (0.39) | SYKCDK2CCNE1CCNT1CDK9 | |
| SCHEMBL18498989 | 0.76 | CCND3 (0.41) | SYKCDK2CDK9CDK4CCNA2 | |
| SCHEMBL14622374 | 0.63 | ACP1 (0.45) | CDK2CCNE1CCNT1CDK9 | |
| SCHEMBL5452864 | 0.60 | CDK2 (0.67) | CDK2CCNE1CDK1 | |
| SCHEMBL2474068 | 0.59 | JAK2 (0.47) | SYKCDK2CCNE1 | |
| SCHEMBL4518931 | 0.59 | POLB (0.42) | SYKMAP4K4 | |
| SCHEMBL31602238 | 0.58 | KCNN3 (0.45) | CDK2DPP4 | |
| SCHEMBL14427340 | 0.57 | TSHR (0.49) | SYKCDK2CCNE1CCNT1CDK9 | |
| SCHEMBL5550263 | 0.57 | S100B (0.53) | MAP4K4 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-9567348-B2 | Substituted pyrazolo[1,5-a]pyrimidines as Syk inhibitors | GILEAD CONNECTICUT, INC. (US) | 2017-02-14 | — | — | US | disclosed |