Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | TYK2 | P29597 | 4/20 | 0.38 |
| ▸ | CDK6 | Q00534 | 3/20 | 0.38 |
| ▸ | CDK2 | P24941 | 2/20 | 0.38 |
| ▸ | CDK4 | P11802 | 2/20 | 0.38 |
| ▸ | CCNE1 | P24864 | 1/20 | 0.38 |
| ▸ | SYK | P43405 | 5/20 | 0.37 |
| ▸ | BTK | Q06187 | 2/20 | 0.36 |
| ▸ | PIM1 | P11309 | 1/20 | 0.36 |
| ▸ | PRKCI | P41743 | 1/20 | 0.36 |
| ▸ | ALOX5 | P09917 | 1/20 | 0.35 |
| ▸ | IKBKE | Q14164 | 3/20 | 0.35 |
| ▸ | TBK1 | Q9UHD2 | 3/20 | 0.35 |
| ▸ | CCNA2 | P20248 | 1/20 | 0.35 |
| ▸ | CCND1 | P24385 | 1/20 | 0.35 |
| ▸ | CCND3 | P30281 | 1/20 | 0.35 |
| ▸ | AXL | P30530 | 1/20 | 0.35 |
| ▸ | FLT3 | P36888 | 1/20 | 0.35 |
| ▸ | TYRO3 | Q06418 | 1/20 | 0.35 |
| ▸ | MERTK | Q12866 | 1/20 | 0.35 |
| ▸ | JAK2 | O60674 | 1/20 | 0.35 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL18499163 | 1.00 | TYK2 (0.38) | TYK2CDK6CDK2CDK4CCNE1 | |
| SCHEMBL2475810 | 0.86 | SYK (0.44) | TYK2CDK6CDK2CDK4CCNE1 | |
| SCHEMBL2473718 | 0.84 | SYK (0.45) | TYK2CDK2CCNE1SYKJAK2 | |
| SCHEMBL2474068 | 0.81 | JAK2 (0.47) | TYK2CDK2CCNE1SYKBTK | |
| SCHEMBL2474769 | 0.80 | MAP3K11 (0.49) | TYK2CDK6CDK2CCNE1SYK | |
| SCHEMBL13288359 | 0.79 | SYK (0.59) | SYKBTKFLT3JAK2 | |
| SCHEMBL2476464 | 0.79 | SYK (0.47) | TYK2CDK2CCNE1SYKBTK | |
| SCHEMBL18498989 | 0.78 | CCND3 (0.41) | TYK2CDK6CDK2CDK4SYK | |
| SCHEMBL18499162 | 0.78 | SYK (0.39) | CDK2CCNE1SYKDPP4 | |
| SCHEMBL2478695 | 0.76 | SYK (0.42) | CDK6CDK4SYKCCND1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-9567348-B2 | Substituted pyrazolo[1,5-a]pyrimidines as Syk inhibitors | GILEAD CONNECTICUT, INC. (US) | 2017-02-14 | — | — | US | disclosed |