Predicted protein targets (top 15)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | SYK | P43405 | 5/20 | 0.39 |
| ▸ | CDK2 | P24941 | 7/20 | 0.34 |
| ▸ | CCNE1 | P24864 | 6/20 | 0.34 |
| ▸ | DPP4 | P27487 | 1/20 | 0.32 |
| ▸ | CCNT1 | O60563 | 2/20 | 0.31 |
| ▸ | CDK9 | P50750 | 2/20 | 0.31 |
| ▸ | NPC1 | O15118 | 1/20 | 0.31 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.31 |
| ▸ | LMNA | P02545 | 1/20 | 0.31 |
| ▸ | POLB | P06746 | 1/20 | 0.31 |
| ▸ | HPGD | P15428 | 1/20 | 0.31 |
| ▸ | HTT | P42858 | 1/20 | 0.31 |
| ▸ | RAB9A | P51151 | 1/20 | 0.31 |
| ▸ | NPSR1 | Q6W5P4 | 1/20 | 0.31 |
| ▸ | RAD52 | P43351 | 2/20 | 0.30 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL2478607 | 0.80 | SYK (0.59) | SYKCDK2CCNE1 | |
| SCHEMBL18498988 | 0.80 | SYK (0.40) | SYKCDK2CCNE1DPP4CCNT1 | |
| SCHEMBL18499161 | 0.78 | TYK2 (0.38) | SYKCDK2CCNE1DPP4 | |
| SCHEMBL18499163 | 0.78 | TYK2 (0.38) | SYKCDK2CCNE1DPP4 | |
| SCHEMBL2473718 | 0.63 | SYK (0.45) | SYKCDK2CCNE1 | |
| SCHEMBL14622374 | 0.59 | ACP1 (0.45) | CDK2CCNE1CCNT1CDK9ALDH1A1 | |
| SCHEMBL2474068 | 0.59 | JAK2 (0.47) | SYKCDK2CCNE1 | |
| SCHEMBL2476464 | 0.59 | SYK (0.47) | SYKCDK2CCNE1NPC1ALDH1A1 | |
| SCHEMBL18498989 | 0.59 | CCND3 (0.41) | SYKCDK2DPP4CDK9 | |
| SCHEMBL13288359 | 0.58 | SYK (0.59) | SYK |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-9567348-B2 | Substituted pyrazolo[1,5-a]pyrimidines as Syk inhibitors | GILEAD CONNECTICUT, INC. (US) | 2017-02-14 | — | — | US | disclosed |