Predicted protein targets (top 4)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | HRH3 | Q9Y5N1 | 2/20 | 0.37 |
| ▸ | SIGMAR1 | Q99720 | 1/20 | 0.33 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.33 |
| ▸ | BCHE | P06276 | 3/20 | 0.31 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL18501245 | 0.90 | HRH3 (0.41) | HRH3SMN1; SMN2 | |
| SCHEMBL16996999 | 0.84 | TSHR (0.39) | SIGMAR1SMN1; SMN2 | |
| SCHEMBL19939276 | 0.83 | HRH3 (0.36) | HRH3SMN1; SMN2 | |
| SCHEMBL12885052 | 0.80 | HRH3 (0.37) | HRH3SMN1; SMN2 | |
| SCHEMBL19591968 | 0.80 | HRH3 (0.46) | HRH3SMN1; SMN2 | |
| SCHEMBL22387981 | 0.79 | PIK3CD (0.44) | SIGMAR1 | |
| SCHEMBL17263240 | 0.78 | HRH3 (0.35) | HRH3 | |
| SCHEMBL25461021 | 0.76 | HRH3 (0.33) | HRH3SMN1; SMN2 | |
| SCHEMBL25461022 | 0.76 | HRH3 (0.33) | HRH3SMN1; SMN2 | |
| SCHEMBL13754476 | 0.76 | DRD2 (0.35) | HRH3 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-9567334-B2 | Quinolone derivatives as fibroblast growth factor receptor inhibitors | PRINCIPIA BIOPHARMA, INC. (US) | 2017-02-14 | — | — | US | disclosed |