Predicted protein targets (top 13)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | CPS1 | P31327 | 13/20 | 0.50 |
| ▸ | GAA | P10253 | 2/20 | 0.46 |
| ▸ | MEN1 | O00255 | 3/20 | 0.42 |
| ▸ | KMT2A | Q03164 | 3/20 | 0.42 |
| ▸ | LMNA | P02545 | 2/20 | 0.42 |
| ▸ | HPGD | P15428 | 2/20 | 0.42 |
| ▸ | ALDH1A1 | P00352 | 2/20 | 0.42 |
| ▸ | ALOX12 | P18054 | 1/20 | 0.42 |
| ▸ | MAPT | P10636 | 2/20 | 0.41 |
| ▸ | NPC1 | O15118 | 1/20 | 0.40 |
| ▸ | RAB9A | P51151 | 1/20 | 0.40 |
| ▸ | APP | P05067 | 1/20 | 0.40 |
| ▸ | SNCA | P37840 | 1/20 | 0.40 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL18489241 | 1.00 | CPS1 (0.50) | CPS1GAAMEN1KMT2ALMNA | |
| SCHEMBL18489238 | 1.00 | CPS1 (0.50) | CPS1GAAMEN1KMT2ALMNA | |
| SCHEMBL29454594 | 0.86 | GAA (0.42) | CPS1GAAMEN1KMT2ALMNA | |
| SCHEMBL18490116 | 0.86 | GAA (0.42) | CPS1GAAMEN1KMT2ALMNA | |
| SCHEMBL18490118 | 0.86 | GAA (0.42) | CPS1GAAMEN1KMT2ALMNA | |
| SCHEMBL22724664 | 0.86 | GAA (0.42) | CPS1GAAMEN1KMT2ALMNA | |
| SCHEMBL20136409 | 0.82 | ALDH1A1 (0.46) | CPS1KMT2AALDH1A1 | |
| SCHEMBL18302342 | 0.82 | CPS1 (0.43) | CPS1MAPTNPC1RAB9A | |
| SCHEMBL20136407 | 0.82 | ALDH1A1 (0.46) | CPS1KMT2AALDH1A1 | |
| SCHEMBL18302344 | 0.82 | CPS1 (0.43) | CPS1MAPTNPC1RAB9A |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 3 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-10428062-B2 | Geminal substituted aminobenzisoxazole compounds as agonists of α7-nicotinic acetylcholine receptors | AXOVANT SCIENCES GMBH (CH) | 2019-10-01 | — | — | US | disclosed |
| US-20170044155-A1 | Geminal Substituted Aminobenzisoxazole Compounds as Agonists of Alpha7-Nicotinic Acetylcholine Receptors | AXOVANT SCIENCES GMBH (CH) | 2017-02-16 | — | — | US | disclosed |
| US-20170044155-A1 | Geminal Substituted Aminobenzisoxazole Compounds as Agonists of Alpha7-Nicotinic Acetylcholine Receptors | AXOVANT SCIENCES GMBH (CH) | 2017-02-16 | — | — | US | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (2 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20170044155-A1 | Geminal Substituted Aminobenzisoxazole Compounds as Agonists of Alpha7-Nicotinic Acetylcholine Receptors | CHRNA7, CHRNA5, CHRNA6 | CPS1 3542/4885GAA 848/4885MEN1 3076/4885 |
| US-10428062-B2 | Geminal substituted aminobenzisoxazole compounds as agonists of α7-nicotinic acetylcholine receptors | CHRNA7, CHRNA5, CHRNA2 | CPS1 3654/4885GAA 966/4885MEN1 3402/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.