Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | ROCK1 | Q13464 | 12/20 | 0.58 |
| ▸ | ROCK2 | O75116 | 12/20 | 0.58 |
| ▸ | MAPK1 | P28482 | 8/20 | 0.58 |
| ▸ | PRKG1 | Q13976 | 5/20 | 0.58 |
| ▸ | RPS6KA5 | O75582 | 4/20 | 0.58 |
| ▸ | PRKACA | P17612 | 4/20 | 0.58 |
| ▸ | RPS6KB1 | P23443 | 4/20 | 0.58 |
| ▸ | CDK2 | P24941 | 4/20 | 0.58 |
| ▸ | GSK3A | P49840 | 4/20 | 0.58 |
| ▸ | GSK3B | P49841 | 4/20 | 0.58 |
| ▸ | PRKX | P51817 | 4/20 | 0.58 |
| ▸ | PRKCD | Q05655 | 4/20 | 0.58 |
| ▸ | PRKG2 | Q13237 | 4/20 | 0.58 |
| ▸ | PKN2 | Q16513 | 4/20 | 0.58 |
| ▸ | CDC42BPA | Q5VT25 | 4/20 | 0.58 |
| ▸ | CLK4 | Q9HAZ1 | 4/20 | 0.58 |
| ▸ | SGK2 | Q9HBY8 | 4/20 | 0.58 |
| ▸ | AKT1 | P31749 | 3/20 | 0.58 |
| ▸ | RPS6KA3 | P51812 | 3/20 | 0.58 |
| ▸ | CDK1 | P06493 | 3/20 | 0.58 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL1853803 | 0.90 | ROCK2 (0.54) | ROCK1ROCK2MAPK1PRKG1RPS6KA5 | |
| SCHEMBL1848838 | 0.83 | ROCK2 (0.47) | ROCK2CSNK1DCHEK1 | |
| SCHEMBL1849102 | 0.83 | GAA (0.53) | ROCK1ROCK2MAPK1MAPK3 | |
| SCHEMBL1851210 | 0.82 | HDAC8 (0.51) | AURKB | |
| SCHEMBL1850045 | 0.81 | SIRT2 (0.54) | ROCK1ROCK2RPS6KB1GSK3AGSK3B | |
| SCHEMBL27490296 | 0.81 | ROCK1 (0.60) | ROCK1ROCK2MAPK1PRKG1RPS6KA5 | |
| SCHEMBL27813525 | 0.81 | MAP2K4 (0.52) | ROCK2MAPK1AURKBCSNK1DALDH1A1 | |
| SCHEMBL1850444 | 0.81 | AURKA (0.47) | ROCK1ROCK2MAPK1MAPK3CYP3A4 | |
| SCHEMBL1846331 | 0.81 | NEK1 (0.43) | ROCK1ROCK2AURKB | |
| Hydrochloric Acid SCHEMBL1848275 | 0.80 | MAP2K4 (0.51) | ROCK2MAPK1AURKBCSNK1DALDH1A1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 17 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-8946250-B2 | 3,4-diarylpyrazoles as protein kinase inhibitors | NERVIANO MEDICAL SCIENCES S.R.L. (IT) | 2015-02-03 | — | — | US | disclosed |
| US-8946250-B2 | 3,4-diarylpyrazoles as protein kinase inhibitors | NERVIANO MEDICAL SCIENCES S.R.L. (IT) | 2015-02-03 | — | — | US | disclosed |
| US-8946250-B2 | 3,4-diarylpyrazoles as protein kinase inhibitors | NERVIANO MEDICAL SCIENCES S.R.L. (IT) | 2015-02-03 | — | — | US | disclosed |
| CN-102105459-B | 3,4-diarylpyrazoles as protein kinase inhibitors | NERVIANO MEDICAL SCIENCES SRL | 2014-09-10 | — | — | CN | disclosed |
| US-20140005150-A1 | 3,4-DIARYLPYRAZOLES AS PROTEIN KINASE INHIBITORS | NERVIANO MEDICAL SCIENCES S.R.L. (IT) | 2014-01-02 | — | — | US | disclosed |
| US-8541575-B2 | 3,4-diarylpyrazoles as protein kinase inhibitors | NERVIANO MEDICAL SCIENCES S.R.L. (IT) | 2013-09-24 | — | — | US | disclosed |
| US-8541575-B2 | 3,4-diarylpyrazoles as protein kinase inhibitors | NERVIANO MEDICAL SCIENCES S.R.L. (IT) | 2013-09-24 | — | — | US | disclosed |
| US-8541575-B2 | 3,4-diarylpyrazoles as protein kinase inhibitors | NERVIANO MEDICAL SCIENCES S.R.L. (IT) | 2013-09-24 | — | — | US | disclosed |
| EP-2324008-B1 | 3,4-DIARYLPYRAZOLES AS PROTEIN KINASE INHIBITORS | NERVIANO MEDICAL SCIENCES SRL (IT) | 2012-05-09 | — | — | EP | disclosed |
| EP-2324008-B1 | 3,4-DIARYLPYRAZOLES AS PROTEIN KINASE INHIBITORS | NERVIANO MEDICAL SCIENCES SRL (IT) | 2012-05-09 | — | — | EP | disclosed |
| CN-102105459-A | 3,4-diarylpyrazoles as protein kinase inhibitors | NERVIANO MEDICAL SCIENCES SRL | 2011-06-22 | — | — | CN | disclosed |
| US-20110144068-A1 | 3,4-DIARYLPYRAZOLES AS PROTEIN KINASE INHIBITORS | NERVIANO MEDICAL SCIENCES S.R.L. (IT) | 2011-06-16 | — | — | US | disclosed |
| US-20110144068-A1 | 3,4-DIARYLPYRAZOLES AS PROTEIN KINASE INHIBITORS | NERVIANO MEDICAL SCIENCES S.R.L. (IT) | 2011-06-16 | — | — | US | disclosed |
| US-20110144068-A1 | 3,4-DIARYLPYRAZOLES AS PROTEIN KINASE INHIBITORS | NERVIANO MEDICAL SCIENCES S.R.L. (IT) | 2011-06-16 | — | — | US | disclosed |
| EP-2324008-A1 | 3,4-DIARYLPYRAZOLES AS PROTEIN KINASE INHIBITORS | NERVIANO MEDICAL SCIENCES S.R.L. (IT) | 2011-05-25 | — | — | EP | disclosed |
| WO-2010010154-A1 | 3,4-DIARYLPYRAZOLES AS PROTEIN KINASE INHIBITORS | NERVIANO MEDICAL SCIENCES S.R.L. (IT) | 2010-01-28 | — | — | WO | disclosed |
| WO-2010010154-A1 | 3,4-DIARYLPYRAZOLES AS PROTEIN KINASE INHIBITORS | NERVIANO MEDICAL SCIENCES S.R.L. (IT) | 2010-01-28 | — | — | WO | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (2 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20140005150-A1 | 3,4-DIARYLPYRAZOLES AS PROTEIN KINASE INHIBITORS | MAP3K3, MAP3K19, MAP3K15 | ROCK1 617/4885ROCK2 648/4885MAPK1 103/4885 |
| US-20110144068-A1 | 3,4-DIARYLPYRAZOLES AS PROTEIN KINASE INHIBITORS | MAP3K3, MAP3K19, MAP3K15 | ROCK1 617/4885ROCK2 648/4885MAPK1 103/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.