Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | ROCK1 | Q13464 | 11/20 | 0.60 |
| ▸ | ROCK2 | O75116 | 10/20 | 0.60 |
| ▸ | MAPK1 | P28482 | 8/20 | 0.60 |
| ▸ | PRKG1 | Q13976 | 5/20 | 0.60 |
| ▸ | RPS6KA5 | O75582 | 4/20 | 0.60 |
| ▸ | PRKACA | P17612 | 4/20 | 0.60 |
| ▸ | RPS6KB1 | P23443 | 4/20 | 0.60 |
| ▸ | CDK2 | P24941 | 4/20 | 0.60 |
| ▸ | GSK3A | P49840 | 4/20 | 0.60 |
| ▸ | GSK3B | P49841 | 4/20 | 0.60 |
| ▸ | PRKX | P51817 | 4/20 | 0.60 |
| ▸ | PRKCD | Q05655 | 4/20 | 0.60 |
| ▸ | PRKG2 | Q13237 | 4/20 | 0.60 |
| ▸ | PKN2 | Q16513 | 4/20 | 0.60 |
| ▸ | CDC42BPA | Q5VT25 | 4/20 | 0.60 |
| ▸ | CLK4 | Q9HAZ1 | 4/20 | 0.60 |
| ▸ | SGK2 | Q9HBY8 | 4/20 | 0.60 |
| ▸ | AKT1 | P31749 | 3/20 | 0.60 |
| ▸ | RPS6KA3 | P51812 | 3/20 | 0.60 |
| ▸ | CDK1 | P06493 | 3/20 | 0.60 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL1850352 | 0.81 | ROCK1 (0.58) | ROCK1ROCK2MAPK1PRKG1RPS6KA5 | |
| SCHEMBL1781134 | 0.79 | ROCK2 (0.51) | ROCK1ROCK2MAPK1PRKG1RPS6KA5 | |
| SCHEMBL1779826 | 0.79 | ROCK2 (0.51) | ROCK1ROCK2MAPK1PRKG1RPS6KA5 | |
| SCHEMBL3093010 | 0.75 | ROCK1 (1.00) | ROCK1ROCK2MAPK1PRKG1RPS6KA5 | |
| SCHEMBL3109948 | 0.75 | ROCK1 (1.00) | ROCK1ROCK2MAPK1PRKG1RPS6KA5 | |
| SCHEMBL1568720 | 0.74 | ROCK2 (0.83) | ROCK1ROCK2MAPK1PRKG1RPS6KA5 | |
| SCHEMBL949150 | 0.74 | CCNC (0.41) | LMNA | |
| SCHEMBL3111975 | 0.72 | ROCK1 (0.75) | ROCK1ROCK2MAPK1PRKG1RPS6KA5 | |
| SCHEMBL3110154 | 0.72 | ROCK1 (0.75) | ROCK1ROCK2MAPK1PRKG1RPS6KA5 | |
| SCHEMBL27556134 | 0.71 | HPGD (0.48) | ROCK1ROCK2MAPK1ALDH1A1HTT |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 4 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| CN-1281604-C | Substituted pyrazole compounds | TEIKOKU HORMONE MFG CO LTD (JP) | 2006-10-25 | — | — | CN | disclosed |
| CN-1560051-A | Substituted pyrazole compounds | �۹���ҩ��ʽ���� | 2005-01-05 | — | — | CN | disclosed |
| CN-1178931-C | Substituted pyrazole compounds | �۹���ҩ��ʽ���� | 2004-12-08 | — | — | CN | disclosed |
| CN-1353704-A | Substituted pyrazole compounds | TEIKOKU HORMONE MFG CO LTD (JP) | 2002-06-12 | — | — | CN | disclosed |