Predicted protein targets (top 16)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | AURKA | O14965 | 1/20 | 0.33 |
| ▸ | PTK2 | Q05397 | 2/20 | 0.33 |
| ▸ | BTK | Q06187 | 1/20 | 0.32 |
| ▸ | CNR2 | P34972 | 3/20 | 0.32 |
| ▸ | CTDSP1 | Q9GZU7 | 1/20 | 0.32 |
| ▸ | FAAH | O00519 | 2/20 | 0.32 |
| ▸ | TRPV1 | Q8NER1 | 2/20 | 0.32 |
| ▸ | STAT6 | P42226 | 1/20 | 0.32 |
| ▸ | BDKRB1 | P46663 | 1/20 | 0.32 |
| ▸ | MAPK9 | P45984 | 1/20 | 0.32 |
| ▸ | MAPK10 | P53779 | 1/20 | 0.32 |
| ▸ | SCD | O00767 | 2/20 | 0.32 |
| ▸ | NTRK1 | P04629 | 1/20 | 0.32 |
| ▸ | MEN1 | O00255 | 1/20 | 0.31 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.31 |
| ▸ | HTT | P42858 | 1/20 | 0.31 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL186530 | 0.90 | TRPV1 (0.34) | AURKAPTK2BTKCTDSP1FAAH | |
| SCHEMBL185703 | 0.89 | FAAH (0.37) | AURKAPTK2BTKCNR2CTDSP1 | |
| SCHEMBL2807585 | 0.87 | CNR2 (0.38) | AURKAPTK2CNR2STAT6BDKRB1 | |
| SCHEMBL186557 | 0.84 | FAAH (0.37) | AURKAPTK2BTKCNR2CTDSP1 | |
| SCHEMBL2809623 | 0.84 | BDKRB1 (0.39) | AURKAPTK2CTDSP1BDKRB1MAPK9 | |
| SCHEMBL186660 | 0.84 | CNR2 (0.36) | PTK2BTKCNR2CTDSP1FAAH | |
| SCHEMBL185009 | 0.84 | BTK (0.37) | AURKAPTK2BTKCNR2CTDSP1 | |
| SCHEMBL185942 | 0.83 | FAAH (0.38) | AURKACTDSP1FAAHTRPV1BDKRB1 | |
| SCHEMBL185912 | 0.83 | AURKA (0.36) | AURKAPTK2CTDSP1FAAHTRPV1 | |
| SCHEMBL185068 | 0.82 | P2RX7 (0.34) | AURKAPTK2CNR2CTDSP1FAAH |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 3 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-2401256-B1 | Compounds as bradykinin B1 antagonists | BOEHRINGER INGELHEIM INT (DE) | 2013-04-17 | — | — | EP | disclosed |
| EP-2401256-A1 | COMPOUNDS AS BRADYKININ B1 ANTAGONISTS | Boehringer Ingelheim International GmbH (DE) | 2012-01-04 | — | — | EP | disclosed |
| WO-2010097372-A1 | COMPOUNDS AS BRADYKININ B1 ANTAGONISTS | BOEHRINGER INGELHEIM INTERNATIONAL GMBH (DE) | 2010-09-02 | — | — | WO | disclosed |