Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | HDAC8 | Q9BY41 | 3/20 | 0.46 |
| ▸ | HDAC3 | O15379 | 2/20 | 0.46 |
| ▸ | HDAC1 | Q13547 | 2/20 | 0.46 |
| ▸ | HDAC2 | Q92769 | 2/20 | 0.46 |
| ▸ | HDAC10 | Q969S8 | 2/20 | 0.46 |
| ▸ | HDAC11 | Q96DB2 | 2/20 | 0.46 |
| ▸ | HDAC6 | Q9UBN7 | 2/20 | 0.46 |
| ▸ | HDAC4 | P56524 | 1/20 | 0.46 |
| ▸ | HDAC7 | Q8WUI4 | 1/20 | 0.46 |
| ▸ | HDAC9 | Q9UKV0 | 1/20 | 0.46 |
| ▸ | HDAC5 | Q9UQL6 | 1/20 | 0.46 |
| ▸ | ITGB3 | P05106 | 2/20 | 0.45 |
| ▸ | ITGAV | P06756 | 2/20 | 0.45 |
| ▸ | ITGA2B | P08514 | 1/20 | 0.45 |
| ▸ | SSTR2 | P30874 | 4/20 | 0.44 |
| ▸ | SSTR5 | P35346 | 4/20 | 0.44 |
| ▸ | SSTR4 | P31391 | 2/20 | 0.44 |
| ▸ | LDLR | P01130 | 1/20 | 0.43 |
| ▸ | PCSK9 | Q8NBP7 | 1/20 | 0.43 |
| ▸ | ROR1 | Q01973 | 1/20 | 0.43 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL18504798 | 1.00 | HDAC8 (0.46) | HDAC8HDAC3HDAC1HDAC2HDAC10 | |
| SCHEMBL22193945 | 0.94 | ITGB3 (0.51) | HDAC8HDAC3HDAC1HDAC2HDAC10 | |
| SCHEMBL22193994 | 0.94 | ITGB3 (0.51) | HDAC8HDAC3HDAC1HDAC2HDAC10 | |
| SCHEMBL24433486 | 0.94 | ITGB3 (0.51) | HDAC8HDAC3HDAC1HDAC2HDAC10 | |
| SCHEMBL22193877 | 0.94 | ITGB3 (0.51) | HDAC8HDAC3HDAC1HDAC2HDAC10 | |
| SCHEMBL18504811 | 0.86 | HDAC8 (0.42) | HDAC8HDAC3HDAC1HDAC2HDAC10 | |
| SCHEMBL18504799 | 0.86 | HDAC8 (0.42) | HDAC8HDAC3HDAC1HDAC2HDAC10 | |
| SCHEMBL18504804 | 0.86 | HDAC8 (0.42) | HDAC8HDAC3HDAC1HDAC2HDAC10 | |
| SCHEMBL18504816 | 0.86 | HDAC8 (0.42) | HDAC8HDAC3HDAC1HDAC2HDAC10 | |
| SCHEMBL18504813 | 0.84 | ITGB3 (0.41) | HDAC8HDAC3HDAC1HDAC2HDAC10 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-20170044236-A1 | Integrin Antagonists | THE GENERAL HOSPITAL CORPORATION | 2017-02-16 | — | — | US | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (1 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20170044236-A1 | Integrin Antagonists | ITGA5, ITGB5, ITGB3 | HDAC8 1204/4885HDAC3 258/4885HDAC1 689/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.