Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | DHODH | Q02127 | 1/20 | 0.39 |
| ▸ | ENPP3 | O14638 | 1/20 | 0.39 |
| ▸ | ENPP1 | P22413 | 1/20 | 0.39 |
| ▸ | LDHA | P00338 | 1/20 | 0.39 |
| ▸ | KDM4E | B2RXH2 | 6/20 | 0.38 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.38 |
| ▸ | GRM5 | P41594 | 2/20 | 0.38 |
| ▸ | KDM6B | O15054 | 1/20 | 0.37 |
| ▸ | KDM4A | O75164 | 1/20 | 0.37 |
| ▸ | KDM5C | P41229 | 1/20 | 0.37 |
| ▸ | KDM4C | Q9H3R0 | 1/20 | 0.37 |
| ▸ | KDM2A | Q9Y2K7 | 1/20 | 0.37 |
| ▸ | KDM3A | Q9Y4C1 | 1/20 | 0.37 |
| ▸ | ALDH1A1 | P00352 | 3/20 | 0.36 |
| ▸ | NPC1 | O15118 | 2/20 | 0.36 |
| ▸ | PKM | P14618 | 2/20 | 0.36 |
| ▸ | HPGD | P15428 | 2/20 | 0.36 |
| ▸ | TP53 | P04637 | 1/20 | 0.36 |
| ▸ | RAB9A | P51151 | 1/20 | 0.36 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.36 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL31393652 | 0.85 | KDM4E (0.46) | DHODHLDHAKDM4EKMT2AGRM5 | |
| SCHEMBL28370241 | 0.75 | SMN1; SMN2 (0.51) | ENPP3ENPP1KDM4EKMT2AGRM5 | |
| SCHEMBL31491743 | 0.73 | CHEK2 (0.53) | KDM4EGRM5NPC1AXLCHEK2 | |
| SCHEMBL1004089 | 0.73 | TP53 (0.42) | KDM4EKMT2AGRM5ALDH1A1NPC1 | |
| SCHEMBL1002385 | 0.73 | GRM5 (0.47) | ENPP3ENPP1KDM4EKMT2AGRM5 | |
| SCHEMBL1001039 | 0.72 | CA2 (0.43) | ENPP3ENPP1KMT2AGRM5PKM | |
| SCHEMBL31039808 | 0.71 | LMNA (0.50) | DHODHKDM4EKMT2AKDM6BKDM4A | |
| SCHEMBL12571344 | 0.71 | LMNA (0.50) | DHODHKDM4EKMT2AKDM6BKDM4A | |
| SCHEMBL12578494 | 0.70 | CA2 (0.40) | ENPP3ENPP1KDM4EKMT2AGRM5 | |
| SCHEMBL17928396 | 0.68 | CCR1 (0.47) | ENPP3ENPP1KDM4EKMT2AGRM5 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-2321288-A1 | OXAZOLE DERIVATIVES USEFUL AS INHIBITORS OF FAAH | Merck & Co., Inc. (US) | 2011-05-18 | — | — | EP | disclosed |
| WO-2010017079-A1 | OXAZOLE DERIVATIVES USEFUL AS INHIBITORS OF FAAH | MERCK & CO., INC. (US) | 2010-02-11 | — | — | WO | disclosed |