Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | POLB | P06746 | 2/20 | 0.34 |
| ▸ | LMNA | P02545 | 2/20 | 0.33 |
| ▸ | CA12 | O43570 | 1/20 | 0.33 |
| ▸ | CA1 | P00915 | 1/20 | 0.33 |
| ▸ | CA2 | P00918 | 1/20 | 0.33 |
| ▸ | CA3 | P07451 | 1/20 | 0.33 |
| ▸ | CA4 | P22748 | 1/20 | 0.33 |
| ▸ | CA6 | P23280 | 1/20 | 0.33 |
| ▸ | CA5A | P35218 | 1/20 | 0.33 |
| ▸ | CA7 | P43166 | 1/20 | 0.33 |
| ▸ | CA9 | Q16790 | 1/20 | 0.33 |
| ▸ | CA13 | Q8N1Q1 | 1/20 | 0.33 |
| ▸ | CA14 | Q9ULX7 | 1/20 | 0.33 |
| ▸ | CA5B | Q9Y2D0 | 1/20 | 0.33 |
| ▸ | L3MBTL1 | Q9Y468 | 2/20 | 0.32 |
| ▸ | KDM4E | B2RXH2 | 2/20 | 0.32 |
| ▸ | NPC1 | O15118 | 2/20 | 0.32 |
| ▸ | RAB9A | P51151 | 2/20 | 0.32 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.32 |
| ▸ | BLM | P54132 | 1/20 | 0.32 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL1848791 | 0.84 | CA1 (0.39) | POLBCA1CA2KDM4EMAPT | |
| SCHEMBL1852826 | 0.78 | ADRA2A (0.39) | KDM4ENPC1RAB9AALDH1A1TDP1 | |
| SCHEMBL1847827 | 0.77 | NPC1 (0.36) | POLBLMNAL3MBTL1KDM4ENPC1 | |
| SCHEMBL2436013 | 0.76 | GAA (0.43) | POLBLMNAKDM4ENPC1RAB9A | |
| SCHEMBL2437157 | 0.75 | ADRA2A (0.39) | KDM4EMAPTSMN1; SMN2KCNH2ATM | |
| SCHEMBL27902043 | 0.74 | MEN1 (0.34) | POLBL3MBTL1ALDH1A1 | |
| SCHEMBL4782064 | 0.73 | APLNR (0.47) | TDP1 | |
| SCHEMBL2434418 | 0.72 | EPHX1 (0.32) | POLBL3MBTL1ALDH1A1MAPTHTT | |
| SCHEMBL2434546 | 0.71 | EPHX1 (0.33) | LMNACA12CA1CA2CA3 | |
| SCHEMBL14307889 | 0.71 | ESR1 (0.37) | POLB |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-2324028-A2 | THERAPEUTIC AGENTS 414 | AstraZeneca AB (SE) | 2011-05-25 | — | — | EP | disclosed |