Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | TSHR | P16473 | 2/20 | 0.45 |
| ▸ | MAPT | P10636 | 1/20 | 0.45 |
| ▸ | CA12 | O43570 | 3/20 | 0.44 |
| ▸ | CA9 | Q16790 | 3/20 | 0.44 |
| ▸ | CSNK2B | P67870 | 12/20 | 0.43 |
| ▸ | CSNK2A2 | P19784 | 8/20 | 0.43 |
| ▸ | PIM1 | P11309 | 11/20 | 0.43 |
| ▸ | PIM3 | Q86V86 | 7/20 | 0.43 |
| ▸ | PIM2 | Q9P1W9 | 7/20 | 0.43 |
| ▸ | CDC7 | O00311 | 6/20 | 0.43 |
| ▸ | CSNK2A1 | P68400 | 6/20 | 0.43 |
| ▸ | CSNK2A3 | Q8NEV1 | 1/20 | 0.43 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.42 |
| ▸ | MEN1 | O00255 | 1/20 | 0.42 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.42 |
| ▸ | HPGD | P15428 | 1/20 | 0.42 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.42 |
| ▸ | HSD17B10 | Q99714 | 1/20 | 0.42 |
| ▸ | L3MBTL1 | Q9Y468 | 1/20 | 0.39 |
| ▸ | NR4A2 | P43354 | 1/20 | 0.39 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL1851701 | 0.81 | CSNK2B (0.58) | CSNK2BCSNK2A2PIM1PIM3PIM2 | |
| SCHEMBL7499641 | 0.74 | TSHR (0.47) | TSHRMAPTCA12CA9CSNK2B | |
| SCHEMBL8117167 | 0.68 | KDM4E (0.58) | TSHRMAPTCA12CA9CSNK2B | |
| SCHEMBL1849708 | 0.68 | CSNK2B (0.60) | CSNK2BCSNK2A2PIM1PIM3PIM2 | |
| SCHEMBL1854409 | 0.67 | PIM1 (0.54) | CSNK2BCSNK2A2PIM1PIM3PIM2 | |
| SCHEMBL15020039 | 0.66 | GAA (0.55) | TSHRMAPTCA12CA9KDM4E | |
| SCHEMBL29853045 | 0.66 | GAA (0.55) | TSHRMAPTCA12CA9KDM4E | |
| SCHEMBL717905 | 0.66 | KCNH2 (0.67) | TSHRMAPTKDM4EMEN1ALDH1A1 | |
| SCHEMBL13748011 | 0.66 | MMP2 (0.50) | TSHRMAPTMEN1ALDH1A1KMT2A | |
| SCHEMBL2761737 | 0.66 | CA12 (0.72) | TSHRMAPTCA12CA9CSNK2B |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 4 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-2097419-B1 | BENZOFUROPYRIMIDINONES AS PROTEIN KINASE INHIBITORS | EXELIXIS INC (US) | 2011-05-25 | — | — | EP | disclosed |
| US-20090247559-A1 | Benzofuropyrimidinones | EXELIXIS, INC. (US) | 2009-10-01 | — | — | US | disclosed |
| US-20090247559-A1 | Benzofuropyrimidinones | EXELIXIS, INC. (US) | 2009-10-01 | — | — | US | disclosed |
| US-20090247559-A1 | Benzofuropyrimidinones | EXELIXIS, INC. (US) | 2009-10-01 | — | — | US | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (1 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20090247559-A1 | Benzofuropyrimidinones | F12, BRI3BP, BRD1 | TSHR 1203/4885MAPT 1941/4885CA12 3842/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.