Predicted protein targets (top 8)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | ALDH1A1 | P00352 | 4/20 | 0.41 |
| ▸ | KDM4E | B2RXH2 | 3/20 | 0.41 |
| ▸ | TDP1 | Q9NUW8 | 2/20 | 0.41 |
| ▸ | AAK1 | Q2M2I8 | 3/20 | 0.39 |
| ▸ | HCAR3 | P49019 | 2/20 | 0.39 |
| ▸ | HDAC1 | Q13547 | 2/20 | 0.37 |
| ▸ | CYP2D6 | P10635 | 1/20 | 0.33 |
| ▸ | HPGD | P15428 | 2/20 | 0.32 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL29719399 | 1.00 | ALDH1A1 (0.41) | ALDH1A1KDM4ETDP1AAK1HCAR3 | |
| SCHEMBL18496294 | 1.00 | ALDH1A1 (0.41) | ALDH1A1KDM4ETDP1AAK1HCAR3 | |
| SCHEMBL18496296 | 1.00 | ALDH1A1 (0.41) | ALDH1A1KDM4ETDP1AAK1HCAR3 | |
| SCHEMBL16489552 | 0.81 | NPC1 (0.41) | ALDH1A1KDM4EHCAR3HDAC1CYP2D6 | |
| SCHEMBL19672450 | 0.81 | NPC1 (0.41) | ALDH1A1KDM4EHCAR3HDAC1CYP2D6 | |
| SCHEMBL18508246 | 0.81 | KDM4E (0.41) | ALDH1A1KDM4ETDP1HCAR3CYP2D6 | |
| SCHEMBL18508300 | 0.81 | KDM4E (0.41) | ALDH1A1KDM4ETDP1HCAR3CYP2D6 | |
| SCHEMBL8200994 | 0.78 | HDAC1 (0.42) | ALDH1A1KDM4EAAK1HDAC1 | |
| SCHEMBL29539178 | 0.78 | HDAC1 (0.42) | ALDH1A1KDM4EAAK1HDAC1 | |
| SCHEMBL4580624 | 0.78 | KDM4E (0.39) | ALDH1A1KDM4ETDP1AAK1HCAR3 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 10 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-20240425481-A1 | SUBSTITUTED BENZIMIDAZOLES, THEIR PREPARATION AND THEIR USE AS PHARMACEUTICALS | EPIGENETIX, INC. | 2024-12-26 | — | — | US | disclosed |
| US-11981657-B2 | Substituted benzimidazoles, their preparation and their use as pharmaceuticals | EPIGENETIX, INC. (US) | 2024-05-14 | — | — | US | disclosed |
| US-20230120413-A1 | SUBSTITUTED BENZIMIDAZOLES, THEIR PREPARATION AND THEIR USE AS PHARMACEUTICALS | NEOMED INSTITUTE (CA) | 2023-04-20 | — | — | US | disclosed |
| US-11365186-B2 | Substituted benzimidazoles, their preparation and their use as pharmaceuticals | EPIGENETIX, INC. (US) | 2022-06-21 | — | — | US | disclosed |
| EP-3334719-B1 | SUBSTITUTED BENZIMIDAZOLES, THEIR PREPARATION AND THEIR USE AS PHARMACEUTICALS | NEOMED INST (CA) | 2021-09-15 | — | — | EP | disclosed |
| EP-3334719-B1 | SUBSTITUTED BENZIMIDAZOLES, THEIR PREPARATION AND THEIR USE AS PHARMACEUTICALS | NEOMED INST (CA) | 2021-09-15 | — | — | EP | disclosed |
| US-20210107893-A1 | SUBSTITUTED BENZIMIDAZOLES, THEIR PREPARATION AND THEIR USE AS PHARMACEUTICALS | EPIGENETIX, INC. | 2021-04-15 | — | — | US | disclosed |
| US-10703740-B2 | Substituted benzimidazoles, their preparation and their use as pharmaceuticals | NEOMED INSTITUTE (CA) | 2020-07-07 | — | — | US | disclosed |
| US-20180237417-A1 | SUBSTITUTED BENZIMIDAZOLES, THEIR PREPARATION AND THEIR USE AS PHARMACEUTICALS | EPIGENETIX, INC. | 2018-08-23 | — | — | US | disclosed |
| WO-2017024412-A1 | SUBSTITUTED BENZIMIDAZOLES, THEIR PREPARATION AND THEIR USE AS PHARMACEUTICALS | NEOMED INSTITUTE (CA) | 2017-02-16 | — | — | WO | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (7 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-11365186-B2 | Substituted benzimidazoles, their preparation and their use as pharmaceuticals | BRD3, BRDT, BRD4 | ALDH1A1 1795/4885KDM4E 398/4885TDP1 845/4885 |
| US-20230120413-A1 | SUBSTITUTED BENZIMIDAZOLES, THEIR PREPARATION AND THEIR USE AS PHARMACEUTICALS | BRD3, BRDT, BRD4 | ALDH1A1 1795/4885KDM4E 398/4885TDP1 845/4885 |
| US-10703740-B2 | Substituted benzimidazoles, their preparation and their use as pharmaceuticals | BRD3, BRDT, BRD4 | ALDH1A1 1795/4885KDM4E 398/4885TDP1 845/4885 |
| US-11981657-B2 | Substituted benzimidazoles, their preparation and their use as pharmaceuticals | BRD3, BRDT, BRD4 | ALDH1A1 1795/4885KDM4E 398/4885TDP1 845/4885 |
| US-20240425481-A1 | SUBSTITUTED BENZIMIDAZOLES, THEIR PREPARATION AND THEIR USE AS PHARMACEUTICALS | BRD3, BRDT, BRD4 | ALDH1A1 1795/4885KDM4E 398/4885TDP1 845/4885 |
| US-20210107893-A1 | SUBSTITUTED BENZIMIDAZOLES, THEIR PREPARATION AND THEIR USE AS PHARMACEUTICALS | BRD3, BRDT, BRD4 | ALDH1A1 1795/4885KDM4E 398/4885TDP1 845/4885 |
| US-20180237417-A1 | SUBSTITUTED BENZIMIDAZOLES, THEIR PREPARATION AND THEIR USE AS PHARMACEUTICALS | BRD3, BRDT, BRD4 | ALDH1A1 1795/4885KDM4E 398/4885TDP1 845/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.